Changes in the patterns of RNA synthesis in early embryogenesis of Xenopus laevis

Koichiro Shiokawa, Yuko Misumi, Kosuke Tashiro, Norihiko Nakakura, K. Yamana, Mamoru Oh-uchida

研究成果: ジャーナルへの寄稿記事

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We analyzed the accumulation of newly-synthesized heterogeneous mRNA-like RNA, 4 S RNA, 5 S RNA, snRNAs and rRNA before and after the midblastula transition (MBT) in Xenopus laevis embryogenesis. Based on the kinetics of the labeling, we concluded that the pattern of RNA synthesis in Xenopus embryogenesis changes following at least three characteristically different phases. The first phase is the pre-MBT stage, which is characterized by the synthesis of heterogeneous mRNA-like RNA, accompanied by the synthesis of small amounts of 4 S RNA, 5 S RNA and snRNAs. The second phase is the MBT stage which is characterized by a large activation (about 50-fold increase on a per cell basis) of 4 S RNA synthesis. The third phase is the post-MBT stage which is characterized by the commencement and increase in rRNA synthesis. We assume that RNA polymerases II, III and I are activated in this order in early Xenopus embryogenesis.

元の言語英語
ページ(範囲)17-25
ページ数9
ジャーナルCell Differentiation and Development
28
発行部数1
DOI
出版物ステータス出版済み - 10 1989

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All Science Journal Classification (ASJC) codes

  • Developmental Biology

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