Characteristic differences according to the cirrhotic pattern of advanced primary biliary cirrhosis: Macronodular cirrhosis indicates slow progression

Shinichi Aishima, Yousuke Kuroda, Yunosuke Nishihara, Kenichi Taguchi, Tomoharu Yoshizumi, Akinobu Taketomi, Yoshihiko Maehara, Masazumi Tsuneyoshi

研究成果: ジャーナルへの寄稿学術誌査読

3 被引用数 (Scopus)

抄録

It is important to evaluate advanced primary biliary cirrhosis (PBC) clinicopathologically to clarify its progressive mechanism. According to the cirrhotic pattern, 26 cases of explanted PBC were classified into non-cirrhotic (n = 4), macronodular (n = 4), mixed nodular (n = 6), and micronodular cirrhosis (n = 12), to compare their clinical and morphological features. In addition, the degree of preserved intrahepatic bile ducts and other histologic features were analyzed. Patients at living donor liver transplantation (LDLT) in the macronodular cirrhosis were significantly older than those in the micronodular cirrhosis. The mean duration between clinical presentation and LDLT in the macronodular cirrhosis was significantly longer than in the micronodular cirrhosis. The non-cirrhotic group showed a short duration between clinical presentation and LDLT. The ratio of explanted liver volume to standard liver volume (ELV/SLV) indicates that macronodular cirrhosis revealed more atrophic change than that in the other three types. The density of remnant intrahepatic bile ducts of less than 50 μm per group in cases of macronodular cirrhosis was significantly higher than that in cases of micronodular cirrhosis. Therefore, different cirrhotic patterns of advanced PBC were correlated with the disease progression and the degree of bile duct disappearance. The macronodular cirrhotic patients were older, had a longer disease course, yet had less bile duct loss. We suggest that macronodular cirrhosis and micronodular cirrhosis of PBC are different type of PBC.

本文言語英語
ページ(範囲)188-194
ページ数7
ジャーナルHepatology Research
36
3
DOI
出版ステータス出版済み - 11月 2006

!!!All Science Journal Classification (ASJC) codes

  • 肝臓学
  • 感染症

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