抄録
It is important to evaluate advanced primary biliary cirrhosis (PBC) clinicopathologically to clarify its progressive mechanism. According to the cirrhotic pattern, 26 cases of explanted PBC were classified into non-cirrhotic (n = 4), macronodular (n = 4), mixed nodular (n = 6), and micronodular cirrhosis (n = 12), to compare their clinical and morphological features. In addition, the degree of preserved intrahepatic bile ducts and other histologic features were analyzed. Patients at living donor liver transplantation (LDLT) in the macronodular cirrhosis were significantly older than those in the micronodular cirrhosis. The mean duration between clinical presentation and LDLT in the macronodular cirrhosis was significantly longer than in the micronodular cirrhosis. The non-cirrhotic group showed a short duration between clinical presentation and LDLT. The ratio of explanted liver volume to standard liver volume (ELV/SLV) indicates that macronodular cirrhosis revealed more atrophic change than that in the other three types. The density of remnant intrahepatic bile ducts of less than 50 μm per group in cases of macronodular cirrhosis was significantly higher than that in cases of micronodular cirrhosis. Therefore, different cirrhotic patterns of advanced PBC were correlated with the disease progression and the degree of bile duct disappearance. The macronodular cirrhotic patients were older, had a longer disease course, yet had less bile duct loss. We suggest that macronodular cirrhosis and micronodular cirrhosis of PBC are different type of PBC.
| 元の言語 | 英語 |
|---|---|
| ページ（範囲） | 188-194 |
| ページ数 | 7 |
| ジャーナル | Hepatology Research |
| 巻 | 36 |
| 発行部数 | 3 |
| DOI | |
| 出版物ステータス | 出版済み - 11 1 2006 |
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All Science Journal Classification (ASJC) codes
- Hepatology
- Infectious Diseases
これを引用
Characteristic differences according to the cirrhotic pattern of advanced primary biliary cirrhosis : Macronodular cirrhosis indicates slow progression. / Aishima, Shinichi; Kuroda, Yohsuke; Nishihara, Yunosuke; Taguchi, Kenichi; Yoshizumi, Tomoharu; Taketomi, Akinobu; Maehara, Yoshihiko; Tsuneyoshi, Masazumi.
：: Hepatology Research, 巻 36, 番号 3, 01.11.2006, p. 188-194.研究成果: ジャーナルへの寄稿 › 記事
}
TY - JOUR
T1 - Characteristic differences according to the cirrhotic pattern of advanced primary biliary cirrhosis
T2 - Macronodular cirrhosis indicates slow progression
AU - Aishima, Shinichi
AU - Kuroda, Yohsuke
AU - Nishihara, Yunosuke
AU - Taguchi, Kenichi
AU - Yoshizumi, Tomoharu
AU - Taketomi, Akinobu
AU - Maehara, Yoshihiko
AU - Tsuneyoshi, Masazumi
PY - 2006/11/1
Y1 - 2006/11/1
N2 - It is important to evaluate advanced primary biliary cirrhosis (PBC) clinicopathologically to clarify its progressive mechanism. According to the cirrhotic pattern, 26 cases of explanted PBC were classified into non-cirrhotic (n = 4), macronodular (n = 4), mixed nodular (n = 6), and micronodular cirrhosis (n = 12), to compare their clinical and morphological features. In addition, the degree of preserved intrahepatic bile ducts and other histologic features were analyzed. Patients at living donor liver transplantation (LDLT) in the macronodular cirrhosis were significantly older than those in the micronodular cirrhosis. The mean duration between clinical presentation and LDLT in the macronodular cirrhosis was significantly longer than in the micronodular cirrhosis. The non-cirrhotic group showed a short duration between clinical presentation and LDLT. The ratio of explanted liver volume to standard liver volume (ELV/SLV) indicates that macronodular cirrhosis revealed more atrophic change than that in the other three types. The density of remnant intrahepatic bile ducts of less than 50 μm per group in cases of macronodular cirrhosis was significantly higher than that in cases of micronodular cirrhosis. Therefore, different cirrhotic patterns of advanced PBC were correlated with the disease progression and the degree of bile duct disappearance. The macronodular cirrhotic patients were older, had a longer disease course, yet had less bile duct loss. We suggest that macronodular cirrhosis and micronodular cirrhosis of PBC are different type of PBC.
AB - It is important to evaluate advanced primary biliary cirrhosis (PBC) clinicopathologically to clarify its progressive mechanism. According to the cirrhotic pattern, 26 cases of explanted PBC were classified into non-cirrhotic (n = 4), macronodular (n = 4), mixed nodular (n = 6), and micronodular cirrhosis (n = 12), to compare their clinical and morphological features. In addition, the degree of preserved intrahepatic bile ducts and other histologic features were analyzed. Patients at living donor liver transplantation (LDLT) in the macronodular cirrhosis were significantly older than those in the micronodular cirrhosis. The mean duration between clinical presentation and LDLT in the macronodular cirrhosis was significantly longer than in the micronodular cirrhosis. The non-cirrhotic group showed a short duration between clinical presentation and LDLT. The ratio of explanted liver volume to standard liver volume (ELV/SLV) indicates that macronodular cirrhosis revealed more atrophic change than that in the other three types. The density of remnant intrahepatic bile ducts of less than 50 μm per group in cases of macronodular cirrhosis was significantly higher than that in cases of micronodular cirrhosis. Therefore, different cirrhotic patterns of advanced PBC were correlated with the disease progression and the degree of bile duct disappearance. The macronodular cirrhotic patients were older, had a longer disease course, yet had less bile duct loss. We suggest that macronodular cirrhosis and micronodular cirrhosis of PBC are different type of PBC.
UR - http://www.scopus.com/inward/record.url?scp=33750045426&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33750045426&partnerID=8YFLogxK
U2 - 10.1016/j.hepres.2006.07.008
DO - 10.1016/j.hepres.2006.07.008
M3 - Article
C2 - 16931135
AN - SCOPUS:33750045426
VL - 36
SP - 188
EP - 194
JO - Hepatology Research
JF - Hepatology Research
SN - 1386-6346
IS - 3
ER -