Characteristics of pancreatic diabetes in patients with autoimmune pancreatitis

Tetsuhide Ito, Taichi Nakamura, Nao Fujimori, Yusuke Niina, Hisato Igarashi, takamasa ono, Masahiko Uchida, Ken Kawabe, Ryoichi Takayanagi, Isao Nishimori, Makoto Otsuki, Tooru Shimosegawa

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

抄録

OBJECTIVE: Although patients with autoimmune pancreatitis (AIP) tend to have concurrent diverse disorders, very few studies have focused on diabetes mellitus (DM) coexisting with AIP. METHODS: In total 102 AIP patients with DM were divided into three groups. Those with DM before the onset of AIP were labeled group A (n=35), those who developed DM and AIP simultaneously were labeled group B (n=58) and those who developed DM after steroid therapy for AIP were labeled group C (n=9). The characteristics of DM among the three groups were evaluated. RESULTS: No significant differences were noted in the age of DM onset among the three groups. However, the mean duration of DM was significantly longer in group A (8.7 years) than in groups B and C. AIP developed 6.8 years after DM onset in group A, whereas it developed 1.8 years after steroid therapy in group C. Group A had the highest rate (25.7%) of family members with a history of AIP. Levels of serum albumin, total cholesterol and triglyceride were significantly lower in group A. No correlations were found between glycated hemoglobin and benzoyl-tyrosyl para-aminobenzoic acid. Hypoglycemia was observed in 20% of patients under insulin therapy. Most of them were habitual drinkers and received no pancreatic enzymes. Group A showed a high prevalence of retinopathy, nephropathy and macrovascular disorders than group B. CONCLUSION: Aspects of AIP-associated pancreatic diabetes were clarified. AIP-associated DM must be controlled by a full assessment of the pancreatic endocrine and exocrine function.

元の言語英語
ページ(範囲)210-216
ページ数7
ジャーナルJournal of Digestive Diseases
12
発行部数3
DOI
出版物ステータス出版済み - 6 1 2011

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Pancreatitis
Diabetes Mellitus
Steroids
4-Aminobenzoic Acid
Glycosylated Hemoglobin A
Group Psychotherapy
Hypoglycemia
Serum Albumin
Triglycerides
Cholesterol
Insulin
Enzymes
Therapeutics

All Science Journal Classification (ASJC) codes

  • Gastroenterology

これを引用

Characteristics of pancreatic diabetes in patients with autoimmune pancreatitis. / Ito, Tetsuhide; Nakamura, Taichi; Fujimori, Nao; Niina, Yusuke; Igarashi, Hisato; ono, takamasa; Uchida, Masahiko; Kawabe, Ken; Takayanagi, Ryoichi; Nishimori, Isao; Otsuki, Makoto; Shimosegawa, Tooru.

:: Journal of Digestive Diseases, 巻 12, 番号 3, 01.06.2011, p. 210-216.

研究成果: ジャーナルへの寄稿記事

Ito, T, Nakamura, T, Fujimori, N, Niina, Y, Igarashi, H, ono, T, Uchida, M, Kawabe, K, Takayanagi, R, Nishimori, I, Otsuki, M & Shimosegawa, T 2011, 'Characteristics of pancreatic diabetes in patients with autoimmune pancreatitis', Journal of Digestive Diseases, 巻. 12, 番号 3, pp. 210-216. https://doi.org/10.1111/j.1751-2980.2011.00498.x
Ito, Tetsuhide ; Nakamura, Taichi ; Fujimori, Nao ; Niina, Yusuke ; Igarashi, Hisato ; ono, takamasa ; Uchida, Masahiko ; Kawabe, Ken ; Takayanagi, Ryoichi ; Nishimori, Isao ; Otsuki, Makoto ; Shimosegawa, Tooru. / Characteristics of pancreatic diabetes in patients with autoimmune pancreatitis. :: Journal of Digestive Diseases. 2011 ; 巻 12, 番号 3. pp. 210-216.
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abstract = "OBJECTIVE: Although patients with autoimmune pancreatitis (AIP) tend to have concurrent diverse disorders, very few studies have focused on diabetes mellitus (DM) coexisting with AIP. METHODS: In total 102 AIP patients with DM were divided into three groups. Those with DM before the onset of AIP were labeled group A (n=35), those who developed DM and AIP simultaneously were labeled group B (n=58) and those who developed DM after steroid therapy for AIP were labeled group C (n=9). The characteristics of DM among the three groups were evaluated. RESULTS: No significant differences were noted in the age of DM onset among the three groups. However, the mean duration of DM was significantly longer in group A (8.7 years) than in groups B and C. AIP developed 6.8 years after DM onset in group A, whereas it developed 1.8 years after steroid therapy in group C. Group A had the highest rate (25.7{\%}) of family members with a history of AIP. Levels of serum albumin, total cholesterol and triglyceride were significantly lower in group A. No correlations were found between glycated hemoglobin and benzoyl-tyrosyl para-aminobenzoic acid. Hypoglycemia was observed in 20{\%} of patients under insulin therapy. Most of them were habitual drinkers and received no pancreatic enzymes. Group A showed a high prevalence of retinopathy, nephropathy and macrovascular disorders than group B. CONCLUSION: Aspects of AIP-associated pancreatic diabetes were clarified. AIP-associated DM must be controlled by a full assessment of the pancreatic endocrine and exocrine function.",
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AU - Ito, Tetsuhide

AU - Nakamura, Taichi

AU - Fujimori, Nao

AU - Niina, Yusuke

AU - Igarashi, Hisato

AU - ono, takamasa

AU - Uchida, Masahiko

AU - Kawabe, Ken

AU - Takayanagi, Ryoichi

AU - Nishimori, Isao

AU - Otsuki, Makoto

AU - Shimosegawa, Tooru

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N2 - OBJECTIVE: Although patients with autoimmune pancreatitis (AIP) tend to have concurrent diverse disorders, very few studies have focused on diabetes mellitus (DM) coexisting with AIP. METHODS: In total 102 AIP patients with DM were divided into three groups. Those with DM before the onset of AIP were labeled group A (n=35), those who developed DM and AIP simultaneously were labeled group B (n=58) and those who developed DM after steroid therapy for AIP were labeled group C (n=9). The characteristics of DM among the three groups were evaluated. RESULTS: No significant differences were noted in the age of DM onset among the three groups. However, the mean duration of DM was significantly longer in group A (8.7 years) than in groups B and C. AIP developed 6.8 years after DM onset in group A, whereas it developed 1.8 years after steroid therapy in group C. Group A had the highest rate (25.7%) of family members with a history of AIP. Levels of serum albumin, total cholesterol and triglyceride were significantly lower in group A. No correlations were found between glycated hemoglobin and benzoyl-tyrosyl para-aminobenzoic acid. Hypoglycemia was observed in 20% of patients under insulin therapy. Most of them were habitual drinkers and received no pancreatic enzymes. Group A showed a high prevalence of retinopathy, nephropathy and macrovascular disorders than group B. CONCLUSION: Aspects of AIP-associated pancreatic diabetes were clarified. AIP-associated DM must be controlled by a full assessment of the pancreatic endocrine and exocrine function.

AB - OBJECTIVE: Although patients with autoimmune pancreatitis (AIP) tend to have concurrent diverse disorders, very few studies have focused on diabetes mellitus (DM) coexisting with AIP. METHODS: In total 102 AIP patients with DM were divided into three groups. Those with DM before the onset of AIP were labeled group A (n=35), those who developed DM and AIP simultaneously were labeled group B (n=58) and those who developed DM after steroid therapy for AIP were labeled group C (n=9). The characteristics of DM among the three groups were evaluated. RESULTS: No significant differences were noted in the age of DM onset among the three groups. However, the mean duration of DM was significantly longer in group A (8.7 years) than in groups B and C. AIP developed 6.8 years after DM onset in group A, whereas it developed 1.8 years after steroid therapy in group C. Group A had the highest rate (25.7%) of family members with a history of AIP. Levels of serum albumin, total cholesterol and triglyceride were significantly lower in group A. No correlations were found between glycated hemoglobin and benzoyl-tyrosyl para-aminobenzoic acid. Hypoglycemia was observed in 20% of patients under insulin therapy. Most of them were habitual drinkers and received no pancreatic enzymes. Group A showed a high prevalence of retinopathy, nephropathy and macrovascular disorders than group B. CONCLUSION: Aspects of AIP-associated pancreatic diabetes were clarified. AIP-associated DM must be controlled by a full assessment of the pancreatic endocrine and exocrine function.

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