Characterization of a Caenorhabditis elegans recA-like gene Ce-rdh-1 involved in meiotic recombination

Takako Takanami, Shusei Sato, Takeshi Ishihara, Isao Katsura, Hideyuki Takahashi, Atsushi Higashitani

研究成果: Contribution to journalArticle査読

36 被引用数 (Scopus)

抄録

A recA-like gene was identified in the Caenorhabditis elegans genome project database. The putative product of the gene, termed Ce-rdh-1 (C. elegans RAD51 and DMC1/LIM15 homolog 1), consists of 357 amino acid residues. The predicted amino acid sequence of Ce-rdh-1 showed 46-60% identity to both RAD51 type and DMC1/LIM15 type genes in several eukaryote species. The results of RNAi (RNA-mediated interference) indicated that repression of Ce-rdh-1 blocked chromosome condensation of six bivalents and dissociation of chiasmata in oocytes of F1 progeny. Oogenesis did not proceed to the diakinesis stage. Accordingly, all the eggs produced (F2) died in early stages. These results suggest that Ce-rdh-1 participates in meiotic recombination.

本文言語英語
ページ(範囲)373-377
ページ数5
ジャーナルDNA Research
5
6
DOI
出版ステータス出版済み - 1998
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 遺伝学

フィンガープリント

「Characterization of a Caenorhabditis elegans recA-like gene Ce-rdh-1 involved in meiotic recombination」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル