Characterization of human pegivirus infection in liver transplantation recipients

Takuma Izumi, Kazuhito Sakata, Daisuke Okuzaki, Shoichi Inokuchi, Tomokazu Tamura, Daisuke Motooka, Shota Nakamura, Chikako Ono, Masahiro Shimokawa, Yoshiharu Matsuura, Masaki Mori, Takasuke Fukuhara, Tomoharu Yoshizumi

研究成果: ジャーナルへの寄稿記事

抄録

Approximately 2% of healthy persons are infected with human pegivirus (HPgV). HPgV is transmitted via vertical, sexual, and blood-borne routes. Recently, the association of HPgV infection with the risk of lymphoma was reported. Here, we examined the prevalence of chronic HPgV infection in liver transplantation (LT) recipients and patients with hepatectomy and the influence of HPgV infection after LT on clinical and perioperative factors. We enrolled 313 LT recipients and 187 patients with hepatectomy who received care at the Kyusyu University Hospital between May 1997 and September 2017. Of the 313 recipients and 187 patients enrolled in this study, 44 recipients (14.1%) and 2 patients (1.1%) had HPgV viremia, respectively. There was no significant association between HPgV infection and LT outcomes. Interestingly, one recipient was infected with HPgV during the peritransplant period, which was likely transmitted via blood transfusion because HPgV RNA was detected from the blood bag transfused to the recipient during LT. We reviewed the available literature on the prevalence HPgV infections in other organ-transplanted patients and whether they impacted clinical outcomes. They also had the higher prevalence of HPgV infection, while it appears to be of low or no consequences. In addition, HPgV infection induced the upregulation of interferon-stimulated gene (ISG) expression in peripheral blood mononuclear cells. LT recipients had higher HPgV viremia compared to patients with hepatectomy. Although HPgV infection was not associated with LT-related outcomes, it induced ISG expression in recipients.

元の言語英語
ページ(範囲)2093-2100
ページ数8
ジャーナルJournal of Medical Virology
91
発行部数12
DOI
出版物ステータス出版済み - 12 1 2019

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Liver Transplantation
Infection
Hepatectomy
Viremia
Interferons
Gene Expression
Blood Transfusion
Lymphoma
Blood Cells
Up-Regulation
RNA

All Science Journal Classification (ASJC) codes

  • Virology
  • Infectious Diseases

これを引用

Characterization of human pegivirus infection in liver transplantation recipients. / Izumi, Takuma; Sakata, Kazuhito; Okuzaki, Daisuke; Inokuchi, Shoichi; Tamura, Tomokazu; Motooka, Daisuke; Nakamura, Shota; Ono, Chikako; Shimokawa, Masahiro; Matsuura, Yoshiharu; Mori, Masaki; Fukuhara, Takasuke; Yoshizumi, Tomoharu.

:: Journal of Medical Virology, 巻 91, 番号 12, 01.12.2019, p. 2093-2100.

研究成果: ジャーナルへの寄稿記事

Izumi, T, Sakata, K, Okuzaki, D, Inokuchi, S, Tamura, T, Motooka, D, Nakamura, S, Ono, C, Shimokawa, M, Matsuura, Y, Mori, M, Fukuhara, T & Yoshizumi, T 2019, 'Characterization of human pegivirus infection in liver transplantation recipients', Journal of Medical Virology, 巻. 91, 番号 12, pp. 2093-2100. https://doi.org/10.1002/jmv.25555
Izumi T, Sakata K, Okuzaki D, Inokuchi S, Tamura T, Motooka D その他. Characterization of human pegivirus infection in liver transplantation recipients. Journal of Medical Virology. 2019 12 1;91(12):2093-2100. https://doi.org/10.1002/jmv.25555
Izumi, Takuma ; Sakata, Kazuhito ; Okuzaki, Daisuke ; Inokuchi, Shoichi ; Tamura, Tomokazu ; Motooka, Daisuke ; Nakamura, Shota ; Ono, Chikako ; Shimokawa, Masahiro ; Matsuura, Yoshiharu ; Mori, Masaki ; Fukuhara, Takasuke ; Yoshizumi, Tomoharu. / Characterization of human pegivirus infection in liver transplantation recipients. :: Journal of Medical Virology. 2019 ; 巻 91, 番号 12. pp. 2093-2100.
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AU - Motooka, Daisuke

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