TY - JOUR
T1 - Characterization of leukaemic basophil progenitors from chronic myelogenous leukaemia
AU - Teshima, Takanori
AU - Kondo, Seiji
AU - Harada, Mine
AU - Shibuya, Tsunefumi
AU - Okamura, Takashi
AU - Tamari, Yuichi
AU - Kimura, Nobuhiro
AU - Akashi, Koichi
AU - Okamura, Seiichi
AU - Niho, Yoshiyuki
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1991/5
Y1 - 1991/5
N2 - Summary We describe the unique characteristics of leukaemic basophils from a patient with chronic myelogenous leukaemia (CML). The leukaemic cells were immature basophil‐like blasts and expressed CD4, CD7 and HLA‐DR in addition to CD13 and CD33. Both immunoglobulin and T cell receptor genes were retained in germline configurations. Interleukin‐1 (IL‐1) or granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) as well as IL‐3 or IL‐4 enhanced the proliferation and differentiation of leukaemic cells and only basophils were generated from in vitro culture. These results suggest that basophil progenitors expressing CD4, CD7 and HLA‐DR may be involved in the development of basophilic crisis of CML and that both IL‐1 and GM‐CSF may act on basophil progenitors as well as IL‐3 or IL‐4.
AB - Summary We describe the unique characteristics of leukaemic basophils from a patient with chronic myelogenous leukaemia (CML). The leukaemic cells were immature basophil‐like blasts and expressed CD4, CD7 and HLA‐DR in addition to CD13 and CD33. Both immunoglobulin and T cell receptor genes were retained in germline configurations. Interleukin‐1 (IL‐1) or granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) as well as IL‐3 or IL‐4 enhanced the proliferation and differentiation of leukaemic cells and only basophils were generated from in vitro culture. These results suggest that basophil progenitors expressing CD4, CD7 and HLA‐DR may be involved in the development of basophilic crisis of CML and that both IL‐1 and GM‐CSF may act on basophil progenitors as well as IL‐3 or IL‐4.
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U2 - 10.1111/j.1365-2141.1991.tb04382.x
DO - 10.1111/j.1365-2141.1991.tb04382.x
M3 - Article
C2 - 2043482
AN - SCOPUS:0025875204
SN - 0007-1048
VL - 78
SP - 55
EP - 59
JO - British Journal of Haematology
JF - British Journal of Haematology
IS - 1
ER -