Characterization of natural killer cells in tamarins: A technical basis for studies of innate immunity

Tomoyuki Yoshida, Akatsuki Saito, Yuki Iwasaki, Sayuki Iijima, Terue Kurosawa, Yuko Katakai, Yasuhiro Yasutomi, Keith A. Reimann, Toshiyuki Hayakawa, Hirofumi Akari

研究成果: Contribution to journalArticle査読

10 被引用数 (Scopus)

抄録

Natural killer (NK) cells are capable of regulating viral infection without major histocompatibility complex restriction. Hepatitis C is caused by chronic infection with hepatitis C virus (HCV), and impaired activity of NK cells may contribute to the control of the disease progression, although the involvement of NK cells in vivo remains to be proven. GB virus B (GBV-B), which is genetically most closely related to HCV, induces acute and chronic hepatitis upon experimental infection of tamarins. This non-human primate model seems likely to be useful for unveiling the roles of NK cells in vivo. Here we characterized the biological phenotypes of NK cells in tamarins and found that depletion of the CD16+ subset in vivo by administration of a monoclonal antibody significantly reduced the number and activity of NK cells.

本文言語英語
ジャーナルFrontiers in Microbiology
1
DEC
DOI
出版ステータス出版済み - 2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • 微生物学
  • 微生物学(医療)

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