Characterization of novel biodegradable segmented polyurethanes prepared from amino-acid based diisocyanate

Atsushi Takahara, Michiko Hadano, Tomohiro Yamaguchi, Hideyuki Otsuka, Satoru Kidoaki, Takehisa Matsuda

研究成果: Contribution to journalArticle査読

27 被引用数 (Scopus)

抄録

Segmented polyurethanes (SPUs) which were expected to yield non-toxic degradation products were synthesized from lysine-based diisocyanate (LDI), 1,3-propanediol (PDO), and polycaprolactone diol (PCL). SPUs were synthesized via a standard two-step prepolymer method. The hard segment fraction was changed in order to tune the mechanical properties and the degradability. The aggregation structures of the SPUs were characterized by infrared spectroscopy and differential scanning calorimetry (DSC), temperature dependence of dynamic viscoelasticity, and small-angle X-ray scattering (SAXS). DSC and dynamic viscoelastic measurements revealed that the glass transition temperature (T g) of the soft segment increased with an increase in the hard segment fraction. SAXS of SPUs revealed the aggregation states of hard and soft segments. Furthermore, the degradation of SPUs was investigated by exposing the polymers to a buffer solution at 310 K (pH=7.6). The degradation rate of SPUs increased with an increase in the soft segment fraction. This is because the soft segment has the hydrolyzable ester linkages and the ester linkages are susceptible to hydrolysis compared with the urethane linkages. Finally, an electrospray deposition method was used to fabricate biodegradable SPU micro-fibers. FE-SEM images showed that higher concentration of solution favored the formation of uniform biodegradable micro-fibers without beads-like structure.

本文言語英語
ページ(範囲)207-218
ページ数12
ジャーナルMacromolecular Symposia
224
DOI
出版ステータス出版済み - 4 2005

All Science Journal Classification (ASJC) codes

  • 凝縮系物理学
  • 有機化学
  • ポリマーおよびプラスチック
  • 材料化学

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