Characterization of the two distinct subtypes of metabotropic glutamate receptors from honeybee, Apis mellifera

Masahiro Funada, Shinobu Yasuo, Takashi Yoshimura, Shizufumi Ebihara, Hiromi Sasagawa, Yasuo Kitagawa, Tatsuhiko Kadowaki

研究成果: Contribution to journalArticle査読

22 被引用数 (Scopus)

抄録

L-Glutamate is a major neurotransmitter at the excitatory synapses in the vertebrate brain. It is also the excitatory neurotransmitter at neuromuscular junctions in insects, however its functions in their brains remain to be established. We identified and characterized two different subtypes (AmGluRA and AmGluRB) of metabotropic glutamate receptors (mGluRs) from an eusocial insect, honeybee. Both AmGluRA and AmGluRB form homodimers independently on disulfide bonds, and bind [3H]glutamate with KD values of 156.7 and 80.7 nM, respectively. AmGluRB is specifically expressed in the brain, while AmGluRA is expressed in the brain and other body parts, suggesting that AmGluRA is also present at the neuromuscular junctions. Both mGluRs are expressed in the mushroom bodies and the brain regions of honeybees, where motor neurons are clustered. Their expression in the brain apparently overlaps, suggesting that they may interact with each other to modulate the glutamatergic neurotransmission.

本文言語英語
ページ(範囲)190-194
ページ数5
ジャーナルNeuroscience Letters
359
3
DOI
出版ステータス出版済み - 4 15 2004
外部発表はい

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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