Characterizing vulnerable brain areas and circuits in mouse models of autism: Towards understanding pathogenesis and new therapeutic approaches

Kelvin Hui, Yuta Katayama, Keiichi I. Nakayama, Jun Nomura, Takeshi Sakurai

研究成果: Contribution to journalReview article査読

6 被引用数 (Scopus)

抄録

Recent human genetics studies have identified many genetic variants that may be responsible for autism spectrum disorder (ASD). ASD mouse models with genetic modifications mimicking these rare genetic variants have provided invaluable mechanistic insights into the disruption of various biological processes and brain areas/circuitry affected in ASD patients. In this review, we begin by reviewing several mouse models for ASD-associated copy number variations (CNVs) to illustrate how they have been employed to establish causal links between their behavioral phenotypes and the affected genes. We then focus on studies using one of the principal behavioral abnormalities associated with ASD, social behavior, to identify the molecular and circuit-level deficits involved. Finally, we end by discussing other mouse models designed to probe how the disruption of specific biological processes such as autophagy and neurogenesis may contribute to ASD pathogenesis. By achieving a greater understanding of the pathophysiology and pathogenic mechanisms involved in ASD and related disorders, novel therapeutic strategies may be devised for ASD patients in the near future.

本文言語英語
ページ(範囲)77-91
ページ数15
ジャーナルNeuroscience and Biobehavioral Reviews
110
DOI
出版ステータス出版済み - 3 2020

All Science Journal Classification (ASJC) codes

  • 神経心理学および生理心理学
  • 認知神経科学
  • 行動神経科学

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