Chemical peeling by SA-PEG remodels photo-damaged skin: Suppressing p53 expression and normalizing keratinocyte differentiation

Teruki Dainichi, Satoshi Amano, Yukiko Matsunaga, Shunsuke Iriyama, Tetsuji Hirao, Takeshi Hariya, Toshihiko Hibino, Chika Katagiri, Motoji Takahashi, Setsuko Ueda, Masutaka Furue

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

抄録

Chemical peeling with salicylic acid in polyethylene glycol vehicle (SA-PEG), which specifically acts on the stratum corneum, suppresses the development of skin tumors in UVB-irradiated hairless mice. To elucidate the mechanism through which chemical peeling with SA-PEG suppresses skin tumor development, the effects of chemical peeling on photodamaged keratinocytes and cornified envelopes (CEs) were evaluated in vivo. Among UVB-irradiated hairless mice, the structural atypia and expression of p53 protein in keratinocytes induced by UVB irradiation were intensely suppressed in the SA-PEG-treated mice 28 days after the start of weekly SA-PEG treatments when compared to that in the control UVB-irradiated mice. Incomplete expression of filaggrin and loricrin in keratinocytes from the control mice was also improved in keratinocytes from the SA-PEG-treated mice. In photo-exposed human facial skin, immature CEs were replaced with mature CEs 4 weeks after treatment with SA-PEG. Restoration of photodamaged stratum corneum by treatment with SA-PEG, which may affect remodeling of the structural environment of the keratinocytes, involved the normalization of keratinocyte differentiation and suppression of skin tumor development. These results suggest that the stratum corneum plays a protective role against carcinogenesis, and provide a novel strategy for the prevention of photo-induced skin tumors.

元の言語英語
ページ(範囲)416-421
ページ数6
ジャーナルJournal of Investigative Dermatology
126
発行部数2
DOI
出版物ステータス出版済み - 2 1 2006

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Peeling
Salicylic Acid
Keratinocytes
Skin
Tumors
Cornea
Hairless Mouse
Neoplasms
Restoration
Carcinogenesis
Irradiation

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

これを引用

Chemical peeling by SA-PEG remodels photo-damaged skin : Suppressing p53 expression and normalizing keratinocyte differentiation. / Dainichi, Teruki; Amano, Satoshi; Matsunaga, Yukiko; Iriyama, Shunsuke; Hirao, Tetsuji; Hariya, Takeshi; Hibino, Toshihiko; Katagiri, Chika; Takahashi, Motoji; Ueda, Setsuko; Furue, Masutaka.

:: Journal of Investigative Dermatology, 巻 126, 番号 2, 01.02.2006, p. 416-421.

研究成果: ジャーナルへの寄稿記事

Dainichi, T, Amano, S, Matsunaga, Y, Iriyama, S, Hirao, T, Hariya, T, Hibino, T, Katagiri, C, Takahashi, M, Ueda, S & Furue, M 2006, 'Chemical peeling by SA-PEG remodels photo-damaged skin: Suppressing p53 expression and normalizing keratinocyte differentiation', Journal of Investigative Dermatology, 巻. 126, 番号 2, pp. 416-421. https://doi.org/10.1038/sj.jid.5700066
Dainichi, Teruki ; Amano, Satoshi ; Matsunaga, Yukiko ; Iriyama, Shunsuke ; Hirao, Tetsuji ; Hariya, Takeshi ; Hibino, Toshihiko ; Katagiri, Chika ; Takahashi, Motoji ; Ueda, Setsuko ; Furue, Masutaka. / Chemical peeling by SA-PEG remodels photo-damaged skin : Suppressing p53 expression and normalizing keratinocyte differentiation. :: Journal of Investigative Dermatology. 2006 ; 巻 126, 番号 2. pp. 416-421.
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abstract = "Chemical peeling with salicylic acid in polyethylene glycol vehicle (SA-PEG), which specifically acts on the stratum corneum, suppresses the development of skin tumors in UVB-irradiated hairless mice. To elucidate the mechanism through which chemical peeling with SA-PEG suppresses skin tumor development, the effects of chemical peeling on photodamaged keratinocytes and cornified envelopes (CEs) were evaluated in vivo. Among UVB-irradiated hairless mice, the structural atypia and expression of p53 protein in keratinocytes induced by UVB irradiation were intensely suppressed in the SA-PEG-treated mice 28 days after the start of weekly SA-PEG treatments when compared to that in the control UVB-irradiated mice. Incomplete expression of filaggrin and loricrin in keratinocytes from the control mice was also improved in keratinocytes from the SA-PEG-treated mice. In photo-exposed human facial skin, immature CEs were replaced with mature CEs 4 weeks after treatment with SA-PEG. Restoration of photodamaged stratum corneum by treatment with SA-PEG, which may affect remodeling of the structural environment of the keratinocytes, involved the normalization of keratinocyte differentiation and suppression of skin tumor development. These results suggest that the stratum corneum plays a protective role against carcinogenesis, and provide a novel strategy for the prevention of photo-induced skin tumors.",
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