Chemistry of planar chiral medium-sized heterocycles

研究成果: ジャーナルへの寄稿評論記事

1 引用 (Scopus)

抄録

Nine-membered E,Z-diallylic heterocycles 1 and [7]-orthocyclphenes 2 exhibit planar chirality at ambient temperature. Their stereochemical stabilities are highly dependent on substituent R1 on the E-Alkene, embedded heteroatom X in the ring, and ring size. Their planar chirality can be transformed into carbon central chirality without loss of enantiopurity. Therefore, they are useful chiral building blocks for biologically active chiral molecules and precursors for chiral reagents. The enantioenriched forms of 1 and 2 are available by optical resolution of racemate, and asymmetric synthesis based on enantioselective cyclization. Planar chiral dialkoxysilane 32 and ketone 33 were also developed.

元の言語英語
ページ(範囲)449-457
ページ数9
ジャーナルYuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry
75
発行部数5
DOI
出版物ステータス出版済み - 1 1 2017

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Chirality
Cyclization
Alkenes
Ketones
Carbon
Molecules
Temperature

All Science Journal Classification (ASJC) codes

  • Organic Chemistry

これを引用

Chemistry of planar chiral medium-sized heterocycles. / Tomooka, Katsuhiko.

:: Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry, 巻 75, 番号 5, 01.01.2017, p. 449-457.

研究成果: ジャーナルへの寄稿評論記事

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