Chemoenzymatically synthesized glycoconjugate polymers

Yoshiko Miura, Takayasu Ikeda, Kazukiyo Kobayashi

研究成果: ジャーナルへの寄稿学術誌査読

80 被引用数 (Scopus)

抄録

Glycoconjugate polymers with poly(vinyl alcohol) (PVA) backbone were synthesized via a chemoenzymatic method. The sugar alcohols of maltose and lactose were submitted to transesterification in the presence of lipases. The esterification was achieved with high selectivity and yield, and the resulting maltitol and lactitol 6-vinyl sebacates were polymerized by a conventional radical initiator with hydrogen peroxide and ascorbic acid. The glycoconjugate polymers carrying α-glucose and β-galactose as recognition signals showed the biological activity such as lectin recognition abilities and hepatocyte adhension. The biodegradability of these polymers was modest but higher than PVA.

本文言語英語
ページ(範囲)410-415
ページ数6
ジャーナルBiomacromolecules
4
2
DOI
出版ステータス出版済み - 3月 1 2003
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • バイオエンジニアリング
  • 生体材料
  • ポリマーおよびプラスチック
  • 材料化学

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