Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx

Katsumasa Nakamura, Yoshiyuki Shioyama, Tomonari Sasaki, Saiji Ohga, Madoka Saku, Yusuke Urashima, Tadamasa Yoshitake, Torahiko Nakashima, Yuichiro Kuratomi, Shizuo Komune, Hiromi Terashima, Hiroshi Honda

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

抄録

Purpose: Early squamous cell carcinoma of the hypopharynx is a rare clinical entity. Our objective was to analyze the outcome of patients with early hypopharyngeal cancer treated with curative radiotherapy or the combination of preoperative radiotherapy with surgery. Methods and Materials: Forty-three patients with Stage I-II hypopharyngeal cancer were initially treated with 30-40 Gy of irradiation with or without chemotherapy. Thirty-two patients (74.4%) who demonstrated a complete response continued to receive further radiotherapy, with a median total dose of 61.2 Gy. Eleven other patients (25.6%) received surgery. Results: Local control with laryngeal voice preservation was achieved in 8 (88.9%) of 9 patients with Stage I disease, and in 23 (67.6%) of 34 patients with Stage II disease. The overall and disease-specific 5-year survival rates for all patients were 70.4% and 89.5%, respectively. The disease-specific survival rates according to the T-category were 100% for patients with T1 disease and 87.2% for patients with T2 disease (p = 0.32). Twenty patients (46.5%) had synchronous or metachronous cancers. Four patients died of hypopharyngeal cancer, and 5 died of second-primary esophageal cancer. Conclusions: A majority of patients with early hypopharyngeal cancer was curable. However, second malignancies influenced the overall outcome of patients with early hypopharyngeal cancer.

元の言語英語
ページ(範囲)680-683
ページ数4
ジャーナルInternational Journal of Radiation Oncology Biology Physics
62
発行部数3
DOI
出版物ステータス出版済み - 7 1 2005

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Hypopharynx
surgery
Squamous Cell Carcinoma
therapy
cancer
Hypopharyngeal Neoplasms
Therapeutics
radiation therapy
Radiotherapy
Second Primary Neoplasms
Survival Rate
chemotherapy
Esophageal Neoplasms

All Science Journal Classification (ASJC) codes

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

これを引用

Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx. / Nakamura, Katsumasa; Shioyama, Yoshiyuki; Sasaki, Tomonari; Ohga, Saiji; Saku, Madoka; Urashima, Yusuke; Yoshitake, Tadamasa; Nakashima, Torahiko; Kuratomi, Yuichiro; Komune, Shizuo; Terashima, Hiromi; Honda, Hiroshi.

:: International Journal of Radiation Oncology Biology Physics, 巻 62, 番号 3, 01.07.2005, p. 680-683.

研究成果: ジャーナルへの寄稿記事

Nakamura, Katsumasa ; Shioyama, Yoshiyuki ; Sasaki, Tomonari ; Ohga, Saiji ; Saku, Madoka ; Urashima, Yusuke ; Yoshitake, Tadamasa ; Nakashima, Torahiko ; Kuratomi, Yuichiro ; Komune, Shizuo ; Terashima, Hiromi ; Honda, Hiroshi. / Chemoradiation therapy with or without salvage surgery for early squamous cell carcinoma of the hypopharynx. :: International Journal of Radiation Oncology Biology Physics. 2005 ; 巻 62, 番号 3. pp. 680-683.
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abstract = "Purpose: Early squamous cell carcinoma of the hypopharynx is a rare clinical entity. Our objective was to analyze the outcome of patients with early hypopharyngeal cancer treated with curative radiotherapy or the combination of preoperative radiotherapy with surgery. Methods and Materials: Forty-three patients with Stage I-II hypopharyngeal cancer were initially treated with 30-40 Gy of irradiation with or without chemotherapy. Thirty-two patients (74.4{\%}) who demonstrated a complete response continued to receive further radiotherapy, with a median total dose of 61.2 Gy. Eleven other patients (25.6{\%}) received surgery. Results: Local control with laryngeal voice preservation was achieved in 8 (88.9{\%}) of 9 patients with Stage I disease, and in 23 (67.6{\%}) of 34 patients with Stage II disease. The overall and disease-specific 5-year survival rates for all patients were 70.4{\%} and 89.5{\%}, respectively. The disease-specific survival rates according to the T-category were 100{\%} for patients with T1 disease and 87.2{\%} for patients with T2 disease (p = 0.32). Twenty patients (46.5{\%}) had synchronous or metachronous cancers. Four patients died of hypopharyngeal cancer, and 5 died of second-primary esophageal cancer. Conclusions: A majority of patients with early hypopharyngeal cancer was curable. However, second malignancies influenced the overall outcome of patients with early hypopharyngeal cancer.",
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AU - Shioyama, Yoshiyuki

AU - Sasaki, Tomonari

AU - Ohga, Saiji

AU - Saku, Madoka

AU - Urashima, Yusuke

AU - Yoshitake, Tadamasa

AU - Nakashima, Torahiko

AU - Kuratomi, Yuichiro

AU - Komune, Shizuo

AU - Terashima, Hiromi

AU - Honda, Hiroshi

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N2 - Purpose: Early squamous cell carcinoma of the hypopharynx is a rare clinical entity. Our objective was to analyze the outcome of patients with early hypopharyngeal cancer treated with curative radiotherapy or the combination of preoperative radiotherapy with surgery. Methods and Materials: Forty-three patients with Stage I-II hypopharyngeal cancer were initially treated with 30-40 Gy of irradiation with or without chemotherapy. Thirty-two patients (74.4%) who demonstrated a complete response continued to receive further radiotherapy, with a median total dose of 61.2 Gy. Eleven other patients (25.6%) received surgery. Results: Local control with laryngeal voice preservation was achieved in 8 (88.9%) of 9 patients with Stage I disease, and in 23 (67.6%) of 34 patients with Stage II disease. The overall and disease-specific 5-year survival rates for all patients were 70.4% and 89.5%, respectively. The disease-specific survival rates according to the T-category were 100% for patients with T1 disease and 87.2% for patients with T2 disease (p = 0.32). Twenty patients (46.5%) had synchronous or metachronous cancers. Four patients died of hypopharyngeal cancer, and 5 died of second-primary esophageal cancer. Conclusions: A majority of patients with early hypopharyngeal cancer was curable. However, second malignancies influenced the overall outcome of patients with early hypopharyngeal cancer.

AB - Purpose: Early squamous cell carcinoma of the hypopharynx is a rare clinical entity. Our objective was to analyze the outcome of patients with early hypopharyngeal cancer treated with curative radiotherapy or the combination of preoperative radiotherapy with surgery. Methods and Materials: Forty-three patients with Stage I-II hypopharyngeal cancer were initially treated with 30-40 Gy of irradiation with or without chemotherapy. Thirty-two patients (74.4%) who demonstrated a complete response continued to receive further radiotherapy, with a median total dose of 61.2 Gy. Eleven other patients (25.6%) received surgery. Results: Local control with laryngeal voice preservation was achieved in 8 (88.9%) of 9 patients with Stage I disease, and in 23 (67.6%) of 34 patients with Stage II disease. The overall and disease-specific 5-year survival rates for all patients were 70.4% and 89.5%, respectively. The disease-specific survival rates according to the T-category were 100% for patients with T1 disease and 87.2% for patients with T2 disease (p = 0.32). Twenty patients (46.5%) had synchronous or metachronous cancers. Four patients died of hypopharyngeal cancer, and 5 died of second-primary esophageal cancer. Conclusions: A majority of patients with early hypopharyngeal cancer was curable. However, second malignancies influenced the overall outcome of patients with early hypopharyngeal cancer.

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