Chest pain without significant coronary stenosis after implantation of sirolimus-eluting stents

Hiasa Ken-Ichi, Masao Takemoto, Ryuichi Matsukawa, Tetsuya Matoba, Takeshi Kuga, Kenji Sunagawa

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

We encountered a case of exercise-induced chest pain after the implantation of sirolimus-eluting stents (SESs). She had no history of previous chest pain, and an exercise stress test just after the implantation of the SESs was negative without any symptoms. However, six months after the implantation of the SESs, she began to experience frequent episodes of severe chest pain on effort in spite of there being no significant coronary stenosis. Interestingly, severe coronary vasoconstriction was induced by an intracoronary administration of acetylcholine, and exercise stress testing revealed positive findings with chest pain and ST-T segment depression on ECG. An intensive treatment with two types of calcium channel blockers could readily and completely abolish the exercise-induced chest pain and ST-T segment depression on the ECG. In view of these findings, we presumed that coronary microvessel dysfunction and/or exercise-induced coronary vasoconstriction leading to myocardial ischemia had appeared 6 months after the implantation of the SESs. Although the pathogenesis of this phenomenon could not be completely elucidated, the anatomical and functional abnormalities of the coronary arteries associated with the implantation of the SESs may have been one of the most important mechanisms.

元の言語英語
ページ(範囲)213-217
ページ数5
ジャーナルInternal Medicine
48
発行部数4
DOI
出版物ステータス出版済み - 3 12 2009

Fingerprint

Coronary Stenosis
Sirolimus
Chest Pain
Stents
Vasoconstriction
Exercise Test
Electrocardiography
Calcium Channel Blockers
Microvessels
Acetylcholine
Myocardial Ischemia
Coronary Vessels

All Science Journal Classification (ASJC) codes

  • Internal Medicine

これを引用

Chest pain without significant coronary stenosis after implantation of sirolimus-eluting stents. / Ken-Ichi, Hiasa; Takemoto, Masao; Matsukawa, Ryuichi; Matoba, Tetsuya; Kuga, Takeshi; Sunagawa, Kenji.

:: Internal Medicine, 巻 48, 番号 4, 12.03.2009, p. 213-217.

研究成果: ジャーナルへの寄稿記事

Ken-Ichi, Hiasa ; Takemoto, Masao ; Matsukawa, Ryuichi ; Matoba, Tetsuya ; Kuga, Takeshi ; Sunagawa, Kenji. / Chest pain without significant coronary stenosis after implantation of sirolimus-eluting stents. :: Internal Medicine. 2009 ; 巻 48, 番号 4. pp. 213-217.
@article{cd6fd20692044a5cbbeb911806e693d8,
title = "Chest pain without significant coronary stenosis after implantation of sirolimus-eluting stents",
abstract = "We encountered a case of exercise-induced chest pain after the implantation of sirolimus-eluting stents (SESs). She had no history of previous chest pain, and an exercise stress test just after the implantation of the SESs was negative without any symptoms. However, six months after the implantation of the SESs, she began to experience frequent episodes of severe chest pain on effort in spite of there being no significant coronary stenosis. Interestingly, severe coronary vasoconstriction was induced by an intracoronary administration of acetylcholine, and exercise stress testing revealed positive findings with chest pain and ST-T segment depression on ECG. An intensive treatment with two types of calcium channel blockers could readily and completely abolish the exercise-induced chest pain and ST-T segment depression on the ECG. In view of these findings, we presumed that coronary microvessel dysfunction and/or exercise-induced coronary vasoconstriction leading to myocardial ischemia had appeared 6 months after the implantation of the SESs. Although the pathogenesis of this phenomenon could not be completely elucidated, the anatomical and functional abnormalities of the coronary arteries associated with the implantation of the SESs may have been one of the most important mechanisms.",
author = "Hiasa Ken-Ichi and Masao Takemoto and Ryuichi Matsukawa and Tetsuya Matoba and Takeshi Kuga and Kenji Sunagawa",
year = "2009",
month = "3",
day = "12",
doi = "10.2169/internalmedicine.48.1581",
language = "English",
volume = "48",
pages = "213--217",
journal = "Internal Medicine",
issn = "0918-2918",
publisher = "Japanese Society of Internal Medicine",
number = "4",

}

TY - JOUR

T1 - Chest pain without significant coronary stenosis after implantation of sirolimus-eluting stents

AU - Ken-Ichi, Hiasa

AU - Takemoto, Masao

AU - Matsukawa, Ryuichi

AU - Matoba, Tetsuya

AU - Kuga, Takeshi

AU - Sunagawa, Kenji

PY - 2009/3/12

Y1 - 2009/3/12

N2 - We encountered a case of exercise-induced chest pain after the implantation of sirolimus-eluting stents (SESs). She had no history of previous chest pain, and an exercise stress test just after the implantation of the SESs was negative without any symptoms. However, six months after the implantation of the SESs, she began to experience frequent episodes of severe chest pain on effort in spite of there being no significant coronary stenosis. Interestingly, severe coronary vasoconstriction was induced by an intracoronary administration of acetylcholine, and exercise stress testing revealed positive findings with chest pain and ST-T segment depression on ECG. An intensive treatment with two types of calcium channel blockers could readily and completely abolish the exercise-induced chest pain and ST-T segment depression on the ECG. In view of these findings, we presumed that coronary microvessel dysfunction and/or exercise-induced coronary vasoconstriction leading to myocardial ischemia had appeared 6 months after the implantation of the SESs. Although the pathogenesis of this phenomenon could not be completely elucidated, the anatomical and functional abnormalities of the coronary arteries associated with the implantation of the SESs may have been one of the most important mechanisms.

AB - We encountered a case of exercise-induced chest pain after the implantation of sirolimus-eluting stents (SESs). She had no history of previous chest pain, and an exercise stress test just after the implantation of the SESs was negative without any symptoms. However, six months after the implantation of the SESs, she began to experience frequent episodes of severe chest pain on effort in spite of there being no significant coronary stenosis. Interestingly, severe coronary vasoconstriction was induced by an intracoronary administration of acetylcholine, and exercise stress testing revealed positive findings with chest pain and ST-T segment depression on ECG. An intensive treatment with two types of calcium channel blockers could readily and completely abolish the exercise-induced chest pain and ST-T segment depression on the ECG. In view of these findings, we presumed that coronary microvessel dysfunction and/or exercise-induced coronary vasoconstriction leading to myocardial ischemia had appeared 6 months after the implantation of the SESs. Although the pathogenesis of this phenomenon could not be completely elucidated, the anatomical and functional abnormalities of the coronary arteries associated with the implantation of the SESs may have been one of the most important mechanisms.

UR - http://www.scopus.com/inward/record.url?scp=61749097292&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=61749097292&partnerID=8YFLogxK

U2 - 10.2169/internalmedicine.48.1581

DO - 10.2169/internalmedicine.48.1581

M3 - Article

VL - 48

SP - 213

EP - 217

JO - Internal Medicine

JF - Internal Medicine

SN - 0918-2918

IS - 4

ER -