Chicken immunoglobulin μ-chain gene: Germline organization and tandem repeats characteristic of class switch recombination

Hiroyuki Kitao, Hiroshi Arakawa, Hideo Yamagishi, Akira Shimizu

研究成果: Contribution to journalArticle査読

15 被引用数 (Scopus)

抄録

We have isolated the phage clones covering the region spanning from the heavy (H)-chain joining (J) region to the end of the μ-chain gene of the chicken immunoglobulin (Ig). The distance from J(H) to the first exon of the μ-chain constant (C) region is approximately 13 kb, and introns between the C region exons measure more than 3 kb. These distances are significantly larger than those of known μ-chain genes. We found a region cross-hybridizing to the switch regions of the mouse Cμ and Cα genes just in front of the first exon of Cμ. Partial nucleotide sequencing of this region revealed that this region consists of tandem repeats of pentamers (C/T)(C/A)CAG complementary to the mammalian switch repetitive region. These findings suggest that this region is a good candidate for a class switch region of the μ-chain gene of chicken Ig.

本文言語英語
ページ(範囲)99-104
ページ数6
ジャーナルImmunology Letters
52
2-3
DOI
出版ステータス出版済み - 9 1996
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫アレルギー学
  • 免疫学

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