Chloracne and hyperpigmentation caused by exposure to hazardous aryl hydrocarbon receptor ligands

Masutaka Furue, Gaku Tsuji

研究成果: Contribution to journalReview article査読

12 被引用数 (Scopus)

抄録

Dioxins and dioxin-like compounds are environmental pollutants that are hazardous to human skin. They can be present in contaminated soil, water, and air particles (such as ambient PM2.5). Exposure to a high concentration of dioxins induces chloracne and hyperpigmentation. These chemicals exert their toxic effects by activating the aryl hydrocarbon receptor (AHR) which is abundantly expressed in skin cells, such as keratinocytes, sebocytes, and melanocytes. Ligation ofAHR by dioxins induces exaggerated acceleration of epidermal terminal differentiation (keratinization) and converts sebocytes toward keratinocyte differentiation, which results in chloracne formation. AHR activation potently upregulates melanogenesis in melanocytes by upregulating the expression of melanogenic enzymes, which results in hyperpigmentation. Because AHR-mediated oxidative stress contributes to these hazardous effects, antioxidative agents may be potentially therapeutic for chloracne and hyperpigmentation.

本文言語英語
論文番号4864
ジャーナルInternational journal of environmental research and public health
16
23
DOI
出版ステータス出版済み - 12 1 2019

All Science Journal Classification (ASJC) codes

  • 公衆衛生学、環境および労働衛生
  • 健康、毒物学および変異誘発

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