Chondroitin sulfate β-1,4-N-acetylgalactosaminyltransferase-1 (ChGn-1) polymorphism

Association with progression of multiple sclerosis

Kazumasa Saigoh, Satoshi Yoshimura, Tomomi Izumikawa, Shinji Miyata, Yasuharu Tabara, Takuya Matsushita, Tetsuro Miki, Katsuichi Miyamoto, Makito Hirano, Hiroshi Kitagawa, Jun-Ichi Kira, Susumu Kusunoki

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

抄録

Chondroitin sulfate proteoglycans (CSPGs) are a constituent of the matrix of the central nervous system (CNS), likely participating as regulatory molecules in the process of demyelination, remyelination, axonal degeneration and regeneration in the CNS. ChGn-1 is a key enzyme for production of CSPGs and knock-out mice of this gene showed better recovery from spinal cord injury. We hypothesized that the clinical course of multiple sclerosis (MS) is influenced by the level of expression of ChGn-1 gene. We recruited 147 patients with MS and 181 healthy control subjects and analyzed single nucleotide polymorphisms (SNPs) of this gene. We found the coding SNP (cSNP: rs140161612) in approximately 10% of patients with MS as well as normal controls. The cSNP is changed from serine to leucine at position 126 (p.S126L). The expressed ChGn-1 mutant proteins exhibited no enzyme activities in COS-1 cells. In men, patients who had MS with S126L had a slower disease progression. This cSNP might be associated with the sex differences in clinical course of MS.

元の言語英語
ページ(範囲)55-59
ページ数5
ジャーナルNeuroscience Research
108
DOI
出版物ステータス出版済み - 7 1 2016

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Multiple Sclerosis
Chondroitin Sulfate Proteoglycans
Single Nucleotide Polymorphism
Central Nervous System
Genes
COS Cells
Demyelinating Diseases
Mutant Proteins
Enzymes
Spinal Cord Injuries
Knockout Mice
Leucine
Sex Characteristics
Serine
Disease Progression
Regeneration
Healthy Volunteers
chondroitin sulfate N-acetylgalactosaminyltransferase-1

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

これを引用

Chondroitin sulfate β-1,4-N-acetylgalactosaminyltransferase-1 (ChGn-1) polymorphism : Association with progression of multiple sclerosis. / Saigoh, Kazumasa; Yoshimura, Satoshi; Izumikawa, Tomomi; Miyata, Shinji; Tabara, Yasuharu; Matsushita, Takuya; Miki, Tetsuro; Miyamoto, Katsuichi; Hirano, Makito; Kitagawa, Hiroshi; Kira, Jun-Ichi; Kusunoki, Susumu.

:: Neuroscience Research, 巻 108, 01.07.2016, p. 55-59.

研究成果: ジャーナルへの寄稿記事

Saigoh, K, Yoshimura, S, Izumikawa, T, Miyata, S, Tabara, Y, Matsushita, T, Miki, T, Miyamoto, K, Hirano, M, Kitagawa, H, Kira, J-I & Kusunoki, S 2016, 'Chondroitin sulfate β-1,4-N-acetylgalactosaminyltransferase-1 (ChGn-1) polymorphism: Association with progression of multiple sclerosis', Neuroscience Research, 巻. 108, pp. 55-59. https://doi.org/10.1016/j.neures.2016.01.002
Saigoh, Kazumasa ; Yoshimura, Satoshi ; Izumikawa, Tomomi ; Miyata, Shinji ; Tabara, Yasuharu ; Matsushita, Takuya ; Miki, Tetsuro ; Miyamoto, Katsuichi ; Hirano, Makito ; Kitagawa, Hiroshi ; Kira, Jun-Ichi ; Kusunoki, Susumu. / Chondroitin sulfate β-1,4-N-acetylgalactosaminyltransferase-1 (ChGn-1) polymorphism : Association with progression of multiple sclerosis. :: Neuroscience Research. 2016 ; 巻 108. pp. 55-59.
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AU - Saigoh, Kazumasa

AU - Yoshimura, Satoshi

AU - Izumikawa, Tomomi

AU - Miyata, Shinji

AU - Tabara, Yasuharu

AU - Matsushita, Takuya

AU - Miki, Tetsuro

AU - Miyamoto, Katsuichi

AU - Hirano, Makito

AU - Kitagawa, Hiroshi

AU - Kira, Jun-Ichi

AU - Kusunoki, Susumu

PY - 2016/7/1

Y1 - 2016/7/1

N2 - Chondroitin sulfate proteoglycans (CSPGs) are a constituent of the matrix of the central nervous system (CNS), likely participating as regulatory molecules in the process of demyelination, remyelination, axonal degeneration and regeneration in the CNS. ChGn-1 is a key enzyme for production of CSPGs and knock-out mice of this gene showed better recovery from spinal cord injury. We hypothesized that the clinical course of multiple sclerosis (MS) is influenced by the level of expression of ChGn-1 gene. We recruited 147 patients with MS and 181 healthy control subjects and analyzed single nucleotide polymorphisms (SNPs) of this gene. We found the coding SNP (cSNP: rs140161612) in approximately 10% of patients with MS as well as normal controls. The cSNP is changed from serine to leucine at position 126 (p.S126L). The expressed ChGn-1 mutant proteins exhibited no enzyme activities in COS-1 cells. In men, patients who had MS with S126L had a slower disease progression. This cSNP might be associated with the sex differences in clinical course of MS.

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