Chromatin remodeling in neural stem cell differentiation

Berry Juliandi, Masahiko Abematsu, Kinichi Nakashima

研究成果: Contribution to journalReview article査読

42 被引用数 (Scopus)

抄録

Chromatin remodeling is a dynamic alteration of chromatin structure that regulates several important biological processes. It is brought about by enzymatic activities that catalyze covalent modifications of histone tail or movement of nucleosomes along the DNA, and these activities often require multisubunit protein complexes for its proper functions. In concert with DNA methylation and noncoding RNA-mediated processes, histone modification such as acetylation and methylation regulates gene expression epigenetically, without affecting DNA sequence. Recent advances have revealed that this intrinsic regulation, together with protein complexes such as RE1 silencer of transcription/neuron-restrictive silencer factor (REST/NRSF) and switch/sucrose nonfermentable (SWI/SNF), play critical roles in neural stem cell fate determination.

本文言語英語
ページ(範囲)408-415
ページ数8
ジャーナルCurrent Opinion in Neurobiology
20
4
DOI
出版ステータス出版済み - 8 2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)

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