Chromatin remodelling in mammalian differentiation: Lessons from ATP-dependent remodellers

Ivana L. De La Serna, Yasuyuki Ohkawa, Anthony N. Imbalzano

研究成果: Contribution to journalReview article査読

298 被引用数 (Scopus)

抄録

The initiation of cellular differentiation involves alterations in gene expression that depend on chromatin changes, at the level of both higher-order structures and individual genes. Consistent with this, chromatin-remodelling enzymes have key roles in differentiation and development. The functions of ATP-dependent chromatin-remodelling enzymes have been studied in several mammalian differentiation pathways, revealing cell-type-specific and gene-specific roles for these proteins that add another layer of precision to the regulation of differentiation. Recent studies have also revealed a role for ATP-dependent remodelling in regulating the balance between proliferation and differentiation, and have uncovered intriguing links between chromatin remodelling and other cellular processes during differentiation, including recombination, genome organization and the cell cycle.

本文言語英語
ページ(範囲)461-473
ページ数13
ジャーナルNature Reviews Genetics
7
6
DOI
出版ステータス出版済み - 6 2006
外部発表はい

All Science Journal Classification (ASJC) codes

  • 分子生物学
  • 遺伝学
  • 遺伝学(臨床)

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