TY - JOUR
T1 - Chromatin remodelling in mammalian differentiation
T2 - Lessons from ATP-dependent remodellers
AU - De La Serna, Ivana L.
AU - Ohkawa, Yasuyuki
AU - Imbalzano, Anthony N.
N1 - Funding Information:
This work was supported by grants from the American Heart Association and the National Institutes of Health (NIH) to I.L.D. and from the NIH to A.N.I. We apologize to those whose work was not discussed due to space limitations.
PY - 2006/6
Y1 - 2006/6
N2 - The initiation of cellular differentiation involves alterations in gene expression that depend on chromatin changes, at the level of both higher-order structures and individual genes. Consistent with this, chromatin-remodelling enzymes have key roles in differentiation and development. The functions of ATP-dependent chromatin-remodelling enzymes have been studied in several mammalian differentiation pathways, revealing cell-type-specific and gene-specific roles for these proteins that add another layer of precision to the regulation of differentiation. Recent studies have also revealed a role for ATP-dependent remodelling in regulating the balance between proliferation and differentiation, and have uncovered intriguing links between chromatin remodelling and other cellular processes during differentiation, including recombination, genome organization and the cell cycle.
AB - The initiation of cellular differentiation involves alterations in gene expression that depend on chromatin changes, at the level of both higher-order structures and individual genes. Consistent with this, chromatin-remodelling enzymes have key roles in differentiation and development. The functions of ATP-dependent chromatin-remodelling enzymes have been studied in several mammalian differentiation pathways, revealing cell-type-specific and gene-specific roles for these proteins that add another layer of precision to the regulation of differentiation. Recent studies have also revealed a role for ATP-dependent remodelling in regulating the balance between proliferation and differentiation, and have uncovered intriguing links between chromatin remodelling and other cellular processes during differentiation, including recombination, genome organization and the cell cycle.
UR - http://www.scopus.com/inward/record.url?scp=33646869229&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33646869229&partnerID=8YFLogxK
U2 - 10.1038/nrg1882
DO - 10.1038/nrg1882
M3 - Review article
C2 - 16708073
AN - SCOPUS:33646869229
VL - 7
SP - 461
EP - 473
JO - Nature Reviews Genetics
JF - Nature Reviews Genetics
SN - 1471-0056
IS - 6
ER -