TY - JOUR
T1 - Chromosomal defects and survival in patients with adult T-cell leukemia/ lymphoma after allogeneic HSCT
AU - Nakano, Nobuaki
AU - Utsunomiya, Atae
AU - Matsuo, Keitaro
AU - Yoshida, Noriaki
AU - Seto, Masao
AU - Ohshima, Kouichi
AU - Fujiwara, Hiroshi
AU - Fuji, Shigeo
AU - Takatsuka, Yoshifusa
AU - Ito, Ayumu
AU - Miyamoto, Toshihiro
AU - Suehiro, Youko
AU - Nakamae, Hirohisa
AU - Sawayama, Yasushi
AU - Yuasa, Mitsuhiro
AU - Miyazaki, Yasuhiko
AU - Ota, Shuichi
AU - Imada, Kazunori
AU - Fukuda, Takahiro
AU - Ichinohe, Tatsuo
AU - Atsuta, Yoshiko
AU - Kato, Koji
N1 - Publisher Copyright:
© 2021 by The American Society of Hematology.
PY - 2021/1/26
Y1 - 2021/1/26
N2 - Adult T-cell leukemia/lymphoma (ATL) cells frequently exhibit chromosomal abnormalities, including numerical aberrations and structural defects. However, no studies have examined the correlation between these abnormalities and survival in patients with ATL after allogeneic HSCT (allo-HSCT). In this study, 300 patients with ATL (median age, 55 years; range, 24-74) who were registered in a Japanese nationwide registry database were analyzed. The majority (n =183) had acute ATL. Specimens for chromosomal analysis were collected from bone marrow (n = 166), lymph nodes (n = 86), peripheral blood (n = 41), and other locations (n = 7). In survival analyses, breakpoints at 2q (hazard ratio [HR], 1.63; 95% confidence interval [CI], 1.12-2.38; P =.012) and 5q (HR, 2.18; 95% CI, 1.25-3.80; P =.006) were significantly poor prognostic factors for overall survival (OS). In terms of ATL-related death, loss of chromosome 14 and breakpoints at 3p, 1q, 5q, and 6q were extracted as significantly poor prognostic factors. Moreover, complex karyotypes were associated with ATL-related death. This study of the survival impact of chromosomal abnormalities in patients with ATL after allo-HSCT demonstrated that several structural breakpoints were independent risk factors for OS and ATL-related death.
AB - Adult T-cell leukemia/lymphoma (ATL) cells frequently exhibit chromosomal abnormalities, including numerical aberrations and structural defects. However, no studies have examined the correlation between these abnormalities and survival in patients with ATL after allogeneic HSCT (allo-HSCT). In this study, 300 patients with ATL (median age, 55 years; range, 24-74) who were registered in a Japanese nationwide registry database were analyzed. The majority (n =183) had acute ATL. Specimens for chromosomal analysis were collected from bone marrow (n = 166), lymph nodes (n = 86), peripheral blood (n = 41), and other locations (n = 7). In survival analyses, breakpoints at 2q (hazard ratio [HR], 1.63; 95% confidence interval [CI], 1.12-2.38; P =.012) and 5q (HR, 2.18; 95% CI, 1.25-3.80; P =.006) were significantly poor prognostic factors for overall survival (OS). In terms of ATL-related death, loss of chromosome 14 and breakpoints at 3p, 1q, 5q, and 6q were extracted as significantly poor prognostic factors. Moreover, complex karyotypes were associated with ATL-related death. This study of the survival impact of chromosomal abnormalities in patients with ATL after allo-HSCT demonstrated that several structural breakpoints were independent risk factors for OS and ATL-related death.
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U2 - 10.1182/bloodadvances.2020003639
DO - 10.1182/bloodadvances.2020003639
M3 - Article
C2 - 33496743
AN - SCOPUS:85099864707
VL - 5
SP - 475
EP - 486
JO - Blood advances
JF - Blood advances
SN - 2473-9529
IS - 2
ER -