Chronic graft-versus-host disease following umbilical cord blood transplantation: Retrospective survey involving 1072 patients in Japan

Hiroto Narimatsu, Shigesaburo Miyakoshi, Takuhiro Yamaguchi, Masahiro Kami, Tomoko Matsumura, Koichiro Yuji, Naoko Murashige, Eiji Kusumi, Yuko Kodama, Tsunehiko Komatsu, Hisashi Sakamaki, Yasushi Kouzai, Masaya Okada, Yuko Osugi, Ryoji Kobayashi, Masami Inoue, Satoshi Takahashi, Shunro Kai, Koji Kato, Tokiko Inoue-NagamuraShuichi Taniguchi, Shunichi Kato

研究成果: ジャーナルへの寄稿学術誌査読

30 被引用数 (Scopus)

抄録

We have little information on chronic graft-versus-host disease (GVHD) after cord blood transplantation (CBT). We investigated its clinical features in 1072 Japanese patients with hematologic malignancies who received a transplant through the Japan Cord Blood Bank Network. The primary end point was to investigate the incidence of any chronic GVHD. Median age of the patients was 33 years (range, 0-79 years). The cumulative incidence of chronic GVHD 2 years after transplantation was 28%. Chronic GVHD was fatal in 29 patients. Multivariate analysis demonstrated that development of chronic GVHD was favorably associated with both overall survival and event-free survival. Multivariate analysis identified risk factors of chronic GVHD: higher patient body weight, higher number of mismatched antigens for GVHD direction, myeloablative preparative regimen, use of mycophenolate mofetil in GVHD prophylaxis, and development of grades II to IV acute GVHD. Although chronic GVHD is a significant problem after CBT, it is associated with improved survival, perhaps due to graft-versus-malignancy effects.

本文言語英語
ページ(範囲)2579-2582
ページ数4
ジャーナルBlood
112
6
DOI
出版ステータス出版済み - 9月 15 2008
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 生化学
  • 免疫学
  • 血液学
  • 細胞生物学

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