Chronic Graft-versus-Host Disease following Varicella-Zoster Virus Infection in Allogeneic Stem Cell Transplant Recipients

Noriaki Kawano, Hisashi Gondo, Tomohiko Kamimura, Kenichi Aoki, Tadafumi Iino, Fumihiko Ishikawa, Toshihiro Miyamoto, Koji Nagafuji, Kazuya Shimoda, Shin Hayashi, Teruhisa Otsuka, Yukumasa Kazuyama, Mine Harada

研究成果: Contribution to journalArticle査読

15 被引用数 (Scopus)

抄録

We describe 2 allogeneic stem cell transplantation patients who developed chronic graft-versus-host disease (GVHD) after dermatomal varicella-zoster virus (VZV) infection. Localized zoster did not respond to oral valaciclovir but did resolve with intravenous aciclovir. However, skin eruptions, eye/oral dryness, and liver dysfunction were observed at the healing stage of localized zoster, suggesting development of GVHD. Intensification of immunosuppressive therapy was required to control GVHD. Quantitative real-time PCR for VZV DNA was used to distinguish liver involvement by chronic GVHD from visceral dissemination of VZV in 1 patient. VZV infection may trigger chronic GVHD after allogeneic stem cell transplantation.

本文言語英語
ページ(範囲)370-373
ページ数4
ジャーナルInternational journal of hematology
78
4
DOI
出版ステータス出版済み - 11 2003

All Science Journal Classification (ASJC) codes

  • Hematology

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