Chronic kidney disease as an independent risk for long-term adverse outcomes in patients hospitalized with heart failure in Japan - Report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)

Sanae Hamaguchi, Miyuki Tsuchihashi-Makaya, Shintaro Kinugawa, Takashi Yokota, Tomomi Ide, Akira Takeshita, Hiroyuki Tsutsui

研究成果: ジャーナルへの寄稿記事

53 引用 (Scopus)

抄録

Background: Previous studies have demonstrated that renal dysfunction is common in patients with heart failure (HF), but it is not known whether chronic kidney disease (CKD) is associated with increased risks of long-term adverse outcomes in unselected HF patients encountered in current routine clinical practice in Japan. Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) prospectively studied a broad sample of patients hospitalized with worsening HF and their outcomes with an average of 2.4 years of follow-up. The study cohort (n=2,013) were classified into 3 groups by estimated glomerular filtration rate (eGFR): ≥60 (n=579), 30-59 (n=1,025), and <30ml·min-1·1.73 m-2 or patients with dialysis (n=409); 1,372 patients (70.3%) had an eGFR <60 ml·min-1·1.73 m-2 and 62 patients were treated with dialysis. The multivariable adjusted risk for all-cause death or rehospitalization increased with reduced eGFR; an adjusted hazard ratio (HR) 1.520 (95% confidence interval (CI) 1.186-1.949) for eGFR 30-59 ml·min-1·1.73 m-2 (P=0.001) and HR 2.566 (95%CI 1.885-3.492) for eGFR <30 ml·min-1·1.73 m-2 or patients with dialysis (P<0.001). Conclusions: CKD is common in HF and was independently associated with long-term adverse outcomes in a broad cohort of Japanese patients.

元の言語英語
ページ(範囲)1442-1447
ページ数6
ジャーナルCirculation Journal
73
発行部数8
DOI
出版物ステータス出版済み - 8 1 2009

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Cardiology
Chronic Renal Insufficiency
Registries
Japan
Heart Failure
Glomerular Filtration Rate
Dialysis
Confidence Intervals
Cause of Death
Cohort Studies
Kidney

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

これを引用

Chronic kidney disease as an independent risk for long-term adverse outcomes in patients hospitalized with heart failure in Japan - Report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD). / Hamaguchi, Sanae; Tsuchihashi-Makaya, Miyuki; Kinugawa, Shintaro; Yokota, Takashi; Ide, Tomomi; Takeshita, Akira; Tsutsui, Hiroyuki.

:: Circulation Journal, 巻 73, 番号 8, 01.08.2009, p. 1442-1447.

研究成果: ジャーナルへの寄稿記事

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title = "Chronic kidney disease as an independent risk for long-term adverse outcomes in patients hospitalized with heart failure in Japan - Report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)",
abstract = "Background: Previous studies have demonstrated that renal dysfunction is common in patients with heart failure (HF), but it is not known whether chronic kidney disease (CKD) is associated with increased risks of long-term adverse outcomes in unselected HF patients encountered in current routine clinical practice in Japan. Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) prospectively studied a broad sample of patients hospitalized with worsening HF and their outcomes with an average of 2.4 years of follow-up. The study cohort (n=2,013) were classified into 3 groups by estimated glomerular filtration rate (eGFR): ≥60 (n=579), 30-59 (n=1,025), and <30ml·min-1·1.73 m-2 or patients with dialysis (n=409); 1,372 patients (70.3{\%}) had an eGFR <60 ml·min-1·1.73 m-2 and 62 patients were treated with dialysis. The multivariable adjusted risk for all-cause death or rehospitalization increased with reduced eGFR; an adjusted hazard ratio (HR) 1.520 (95{\%} confidence interval (CI) 1.186-1.949) for eGFR 30-59 ml·min-1·1.73 m-2 (P=0.001) and HR 2.566 (95{\%}CI 1.885-3.492) for eGFR <30 ml·min-1·1.73 m-2 or patients with dialysis (P<0.001). Conclusions: CKD is common in HF and was independently associated with long-term adverse outcomes in a broad cohort of Japanese patients.",
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T1 - Chronic kidney disease as an independent risk for long-term adverse outcomes in patients hospitalized with heart failure in Japan - Report from the Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD)

AU - Hamaguchi, Sanae

AU - Tsuchihashi-Makaya, Miyuki

AU - Kinugawa, Shintaro

AU - Yokota, Takashi

AU - Ide, Tomomi

AU - Takeshita, Akira

AU - Tsutsui, Hiroyuki

PY - 2009/8/1

Y1 - 2009/8/1

N2 - Background: Previous studies have demonstrated that renal dysfunction is common in patients with heart failure (HF), but it is not known whether chronic kidney disease (CKD) is associated with increased risks of long-term adverse outcomes in unselected HF patients encountered in current routine clinical practice in Japan. Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) prospectively studied a broad sample of patients hospitalized with worsening HF and their outcomes with an average of 2.4 years of follow-up. The study cohort (n=2,013) were classified into 3 groups by estimated glomerular filtration rate (eGFR): ≥60 (n=579), 30-59 (n=1,025), and <30ml·min-1·1.73 m-2 or patients with dialysis (n=409); 1,372 patients (70.3%) had an eGFR <60 ml·min-1·1.73 m-2 and 62 patients were treated with dialysis. The multivariable adjusted risk for all-cause death or rehospitalization increased with reduced eGFR; an adjusted hazard ratio (HR) 1.520 (95% confidence interval (CI) 1.186-1.949) for eGFR 30-59 ml·min-1·1.73 m-2 (P=0.001) and HR 2.566 (95%CI 1.885-3.492) for eGFR <30 ml·min-1·1.73 m-2 or patients with dialysis (P<0.001). Conclusions: CKD is common in HF and was independently associated with long-term adverse outcomes in a broad cohort of Japanese patients.

AB - Background: Previous studies have demonstrated that renal dysfunction is common in patients with heart failure (HF), but it is not known whether chronic kidney disease (CKD) is associated with increased risks of long-term adverse outcomes in unselected HF patients encountered in current routine clinical practice in Japan. Methods and Results: The Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) prospectively studied a broad sample of patients hospitalized with worsening HF and their outcomes with an average of 2.4 years of follow-up. The study cohort (n=2,013) were classified into 3 groups by estimated glomerular filtration rate (eGFR): ≥60 (n=579), 30-59 (n=1,025), and <30ml·min-1·1.73 m-2 or patients with dialysis (n=409); 1,372 patients (70.3%) had an eGFR <60 ml·min-1·1.73 m-2 and 62 patients were treated with dialysis. The multivariable adjusted risk for all-cause death or rehospitalization increased with reduced eGFR; an adjusted hazard ratio (HR) 1.520 (95% confidence interval (CI) 1.186-1.949) for eGFR 30-59 ml·min-1·1.73 m-2 (P=0.001) and HR 2.566 (95%CI 1.885-3.492) for eGFR <30 ml·min-1·1.73 m-2 or patients with dialysis (P<0.001). Conclusions: CKD is common in HF and was independently associated with long-term adverse outcomes in a broad cohort of Japanese patients.

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JO - Circulation Journal

JF - Circulation Journal

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