Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors

Hiroaki Ogata, Isamu Okamoto, Goichi Yoshimoto, Teppei Obara, Kayo Ijichi, Eiji Iwama, Taishi Harada, Koichi Akashi, Yoichi Nakanishi

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

A 59-year-old woman with epidermal growth factor receptor gene (EGFR) mutation–positive advanced lung adenocarcinoma was treated with afatinib after a diagnosis of chronic myelomonocytic leukemia (CMML). Twenty-one weeks later, she developed agranulocytosis, and CMML subsequently progressed to blast crisis. After complete remission of CMML, gefitinib was initiated; however, agranulocytosis recurred. This is the first reported case of both EGFR mutation–positive advanced non-small cell lung cancer with CMML, and of CMML blast crisis. Physicians should be aware of such risks and monitor EGFR-TKI–treated patients with myeloid neoplasms accordingly.

元の言語英語
ページ(範囲)181-183
ページ数3
ジャーナルRespiratory Investigation
55
発行部数2
DOI
出版物ステータス出版済み - 3 1 2017

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Leukemia, Myelomonocytic, Chronic
erbB-1 Genes
Blast Crisis
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Agranulocytosis
Physicians
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine

これを引用

Chronic myelomonocytic leukemia blast crisis in a patient with advanced non-small cell lung cancer treated with EGFR tyrosine kinase inhibitors. / Ogata, Hiroaki; Okamoto, Isamu; Yoshimoto, Goichi; Obara, Teppei; Ijichi, Kayo; Iwama, Eiji; Harada, Taishi; Akashi, Koichi; Nakanishi, Yoichi.

:: Respiratory Investigation, 巻 55, 番号 2, 01.03.2017, p. 181-183.

研究成果: ジャーナルへの寄稿記事

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AU - Ijichi, Kayo

AU - Iwama, Eiji

AU - Harada, Taishi

AU - Akashi, Koichi

AU - Nakanishi, Yoichi

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