Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly

Shuji Murakami, Hiroki Imbe, Yoshihiro Morikawa, Chiharu Kubo, Emiko Senba

研究成果: Contribution to journalArticle査読

259 被引用数 (Scopus)


Daily restraint for 3 weeks was shown to atrophy dendrites of hippocampal pyramidal neurons in rats. Brain-derived neurotrophic factor (BDNF), which maintains neuronal survival and morphology, has been shown to decrease in response to acute stress. Plasma glucocorticoid (GC) and serotonergic projections from the raphe nuclei play major roles in reducing BDNF synthesis in the hippocampus. We investigated BDNF mRNA levels there, together with plasma GC levels, GC receptors in the hippocampus/hypothalamus and 5-HT synthesizing enzyme, tryptophan hydroxylase in the raphe nuclei, in animals chronically stressed for 1-3 weeks, using in situ hybridization and immunohistochemistry. In these animals, BDNF mRNA levels were significantly decreased in the hippocampus after 6 h of restraint, but the ability of restraint to reduce BDNF synthesis seemed less robust than that seen in acute stress models. HPA axis response to stress in these animals assessed by plasma GC levels was delayed and sustained, and the GC receptor in the paraventricular hypothalamic nucleus was increased at 1 week. Tryptophan hydroxylase immunoreactivity was increased in the median raphe nucleus at 2-3 weeks. Repetitive stress-induced reduction of BDNF may partly contribute to the neuronal atrophy/death and reduction of hippocampal volume observed both in animals and humans suffering chronic stress and/or depression.

ジャーナルNeuroscience Research
出版ステータス出版済み - 10 2005

All Science Journal Classification (ASJC) codes

  • 神経科学(全般)


「Chronic stress, as well as acute stress, reduces BDNF mRNA expression in the rat hippocampus but less robustly」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。