Chronic thrombopoietin overexpression induces mesangioproliferative glomerulopathy in mice

Haruko K. Shimoda, Masahiro Yamamoto, Kotaro Shide, Kenjirou Kamezaki, Tadashi Matsuda, Katsuhiro Ogawa, Mine Harada, Kazuya Shimoda

研究成果: ジャーナルへの寄稿学術誌査読

5 被引用数 (Scopus)

抄録

We previously reported that mice transgenic (Tg) for thrombopoietin (TPO) developed progressive fibrosis and osteosclerosis of the bone marrow. Here, we show that TPO-overexpressing mice also exhibited notable histological changes in the kidneys, including an increased number of mesangial cells, expansion of the mesangial matrix in the glomerulus, and atrophy of the renal tubuli. Plasma transforming growth factor (TGF)-β1 and platelet-derived growth factor (PDGF)-BB, which could induce mesangioproliferative responses in glomeruli, were both elevated in TPO Tg mice, even though TPO itself has no effect on mesangial cells due to their lack of c-Mpl. The mesangial proliferative change in TPO Tg mice was thought to be induced by the elevation of these cytokines. In conclusion, our finding that TPO-overexpressing mice developed mesangioproliferative glomerulopathy might represent an undesirable effect of chronically elevated TPO in vivo, which should be taken into consideration before new TPO-like growth factors become available in clinical practice.

本文言語英語
ページ(範囲)802-806
ページ数5
ジャーナルAmerican Journal of Hematology
82
9
DOI
出版ステータス出版済み - 9月 2007
外部発表はい

!!!All Science Journal Classification (ASJC) codes

  • 血液学

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