Chronic toxicity of indium arsenide and indium phosphide to the lungs of hamsters.

A. Tanaka, A. Hisanaga, M. Hirata, M. Omura, Y. Makita, N. Inoue, N. Ishinishi

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)

抄録

Chronic toxicity of indium arsenide (InAs) and indium phosphide (InP) was studied in male Syrian golden hamsters which received InAs or InP particles containing a total dose of 7.5 mg of arsenic or phosphorus by intratracheal instillations once a week for 15 weeks. As a control, hamsters were treated with the vehicle, phosphate buffer solution. During their total life span, the cumulative body weight gain of hamsters in the InAs group was suppressed significantly compared with that in the control group, but not in the InP group when compared with that in the control group. Concerning the histopathological findings of the lung, the incidence rates of proteinosis-like lesions, alveolar or bronchiolar cell hyperplasia, pneumonia, emphysema and metaplastic ossification observed in the InAs or InP group were significantly higher than those observed in the control group. From these results, it would seem that InAs and InP produced severe damage to the lungs of hamsters.

元の言語英語
ページ(範囲)108-115
ページ数8
ジャーナルFukuoka igaku zasshi = Hukuoka acta medica
87
発行部数5
出版物ステータス出版済み - 5 1996

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Cricetinae
Lung
Control Groups
Mesocricetus
Emphysema
Arsenic
Osteogenesis
Phosphorus
Weight Gain
Hyperplasia
Pneumonia
Buffers
Phosphates
Body Weight
indium phosphide
indium arsenide
Incidence

All Science Journal Classification (ASJC) codes

  • Medicine(all)

これを引用

Chronic toxicity of indium arsenide and indium phosphide to the lungs of hamsters. / Tanaka, A.; Hisanaga, A.; Hirata, M.; Omura, M.; Makita, Y.; Inoue, N.; Ishinishi, N.

:: Fukuoka igaku zasshi = Hukuoka acta medica, 巻 87, 番号 5, 05.1996, p. 108-115.

研究成果: ジャーナルへの寄稿記事

Tanaka, A, Hisanaga, A, Hirata, M, Omura, M, Makita, Y, Inoue, N & Ishinishi, N 1996, 'Chronic toxicity of indium arsenide and indium phosphide to the lungs of hamsters.', Fukuoka igaku zasshi = Hukuoka acta medica, 巻. 87, 番号 5, pp. 108-115.
Tanaka, A. ; Hisanaga, A. ; Hirata, M. ; Omura, M. ; Makita, Y. ; Inoue, N. ; Ishinishi, N. / Chronic toxicity of indium arsenide and indium phosphide to the lungs of hamsters. :: Fukuoka igaku zasshi = Hukuoka acta medica. 1996 ; 巻 87, 番号 5. pp. 108-115.
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title = "Chronic toxicity of indium arsenide and indium phosphide to the lungs of hamsters.",
abstract = "Chronic toxicity of indium arsenide (InAs) and indium phosphide (InP) was studied in male Syrian golden hamsters which received InAs or InP particles containing a total dose of 7.5 mg of arsenic or phosphorus by intratracheal instillations once a week for 15 weeks. As a control, hamsters were treated with the vehicle, phosphate buffer solution. During their total life span, the cumulative body weight gain of hamsters in the InAs group was suppressed significantly compared with that in the control group, but not in the InP group when compared with that in the control group. Concerning the histopathological findings of the lung, the incidence rates of proteinosis-like lesions, alveolar or bronchiolar cell hyperplasia, pneumonia, emphysema and metaplastic ossification observed in the InAs or InP group were significantly higher than those observed in the control group. From these results, it would seem that InAs and InP produced severe damage to the lungs of hamsters.",
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T1 - Chronic toxicity of indium arsenide and indium phosphide to the lungs of hamsters.

AU - Tanaka, A.

AU - Hisanaga, A.

AU - Hirata, M.

AU - Omura, M.

AU - Makita, Y.

AU - Inoue, N.

AU - Ishinishi, N.

PY - 1996/5

Y1 - 1996/5

N2 - Chronic toxicity of indium arsenide (InAs) and indium phosphide (InP) was studied in male Syrian golden hamsters which received InAs or InP particles containing a total dose of 7.5 mg of arsenic or phosphorus by intratracheal instillations once a week for 15 weeks. As a control, hamsters were treated with the vehicle, phosphate buffer solution. During their total life span, the cumulative body weight gain of hamsters in the InAs group was suppressed significantly compared with that in the control group, but not in the InP group when compared with that in the control group. Concerning the histopathological findings of the lung, the incidence rates of proteinosis-like lesions, alveolar or bronchiolar cell hyperplasia, pneumonia, emphysema and metaplastic ossification observed in the InAs or InP group were significantly higher than those observed in the control group. From these results, it would seem that InAs and InP produced severe damage to the lungs of hamsters.

AB - Chronic toxicity of indium arsenide (InAs) and indium phosphide (InP) was studied in male Syrian golden hamsters which received InAs or InP particles containing a total dose of 7.5 mg of arsenic or phosphorus by intratracheal instillations once a week for 15 weeks. As a control, hamsters were treated with the vehicle, phosphate buffer solution. During their total life span, the cumulative body weight gain of hamsters in the InAs group was suppressed significantly compared with that in the control group, but not in the InP group when compared with that in the control group. Concerning the histopathological findings of the lung, the incidence rates of proteinosis-like lesions, alveolar or bronchiolar cell hyperplasia, pneumonia, emphysema and metaplastic ossification observed in the InAs or InP group were significantly higher than those observed in the control group. From these results, it would seem that InAs and InP produced severe damage to the lungs of hamsters.

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