Chronopharmacological study of KE-SI-TO in mice

Nobuya Ogawa, Shigehiro Ohdo, Jian Guo Song, Shun Higuchi

研究成果: Contribution to journalArticle査読

5 被引用数 (Scopus)

抄録

Influence of dosing time on pharmacological effects and toxicity of KE- SI-TO (KST), analgesic and antipyretic drug, was investigated in ICR male mice under LD (12:12) cycle. Significant circadian rhythms were demonstrated for analgesic and hypothermal effects of KST (1 g/kg, i.p.) with higher values in the dark and lower ones in the light (p<0.01, respectively). The rhythmic patterns of KST-induced analgesia and hypothermia resembled overall the rhythms occuring in the nondrugged state. Injection of KST resulted in a parallel increasing in latency to hot plate and a parallel decreasing in rectal temperature. KST (6 g/kg, i.p.)induced toxicity also showed a significant circadian rhythm with the highest mortality at 1700 and the lowest one at 0500 (p<0.05). The principles and concepts of biological rhythm should be included in the consideration of the actions of KST.

本文言語英語
ページ(範囲)2091-2098
ページ数8
ジャーナルLife Sciences
60
23
DOI
出版ステータス出版済み - 5 2 1997

All Science Journal Classification (ASJC) codes

  • 生化学、遺伝学、分子生物学(全般)
  • 薬理学、毒性学および薬学(全般)

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