Churg-Strauss syndrome associated with elevated levels of serum interleukin-5 and T cell receptor-Cβ gene rearrangement

Yoshiro Horai, Tomoya Miyamura, Soichiro Takahama, Akie Hirata, Masataka Nakamura, Hitoshi Ando, Rumi Minami, Masahiro Yamamoto, Eiichi Suematsu

研究成果: Contribution to journalArticle

6 引用 (Scopus)

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A 58-year-old woman was diagnosed with Churg-Strauss syndrome (CSS) based on the symptoms of bronchial asthma, eosinophilia, mononeuritis multiplex and histological examination of the right sural nerve. Prior to treatment, the serum interleukin (IL)-5 level was high, and rearrangement of the T cell receptor (TCR) gene was identified. This is the first report of TCR gene rearrangement in a patient with CSS. The expanded T cell clone may be responsible for the overproduction of IL-5. Further studies are warranted to disclose a prevalence of TCR gene rearrangement in CSS patients and its pathophysiological roles in the development of this disease.

元の言語英語
ページ(範囲)76-78
ページ数3
ジャーナルModern Rheumatology
21
発行部数1
DOI
出版物ステータス出版済み - 2 1 2011
外部発表Yes

All Science Journal Classification (ASJC) codes

  • Rheumatology

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    Horai, Y., Miyamura, T., Takahama, S., Hirata, A., Nakamura, M., Ando, H., Minami, R., Yamamoto, M., & Suematsu, E. (2011). Churg-Strauss syndrome associated with elevated levels of serum interleukin-5 and T cell receptor-Cβ gene rearrangement. Modern Rheumatology, 21(1), 76-78. https://doi.org/10.1007/s10165-010-0341-3