Cigarette smoking, alcohol consumption, and risk of systemic lupus erythematosus: A case-control study in a Japanese population

Chikako Kiyohara, Masakazu Washio, Takahiko Horiuchi, Toyoko Asami, Saburo Ide, Tatsuya Atsumi, Gen Kobashi, Yoshifumi Tada, Hiroki Takahashi, Hiroko Kodama, Koichi Akashi, Mine Harada, Hiroaki Niiro, Hiroshi Tsukamoto, Takao Hotokebuchi, Kohei Nagasawa, Osamu Ushiyama, Mitsuru Mori, Asae Oura, Yasuhisa SinomuraHiromu Suzuki, Motohisa Yamamoto, Tetsuya Horita, Takao Koike, Takashi Abe, Hisato Tanaka, Norihiko Nogami, Kazushi Okamoto, Naomasa Sakamoto, Satoshi Sasaki, Yoshihiro Miyake, Tetsuji Yokoyama, Yoshio Hirota, Yutaka Inaba, Masaki Nagai

研究成果: Contribution to journalArticle

35 引用 (Scopus)

抜粋

Objective. Cigarette smoking may be associated with increased risk of systemic lupus erythematosus (SLE), whereas the role of alcohol consumption is unknown. We examined the association between SLE risk and smoking or drinking. Methods. We investigated the relationship of smoking and drinking compared to SLE risk among 171 SLE cases and 492 healthy controls in female Japanese subjects. Unconditional logistic regression was used to compute OR and 95% CI, with adjustments for several covariates. Results. Compared with nonsmoking, current smoking was significantly associated with increased risk of SLE (OR 3.06, 95% CI 1.86-5.03). The higher the level of exposure to cigarette smoke, the higher the risk of SLE. Inhalation was also associated with increased SLE risk (OR 3.73, 95% CI 1.46-9.94 for moderate inhalation; OR 3.06, 95% CI 1.81-5.15 for deep inhalation). In contrast, light/moderate alcohol consumption had a protective effect on SLE risk (OR 0.38, 95% CI 0.19-0.76). As for beer, the risks for non-beer drinkers and beer drinkers were similar. This also applies to alcoholic beverages other than beer. Conclusion. Our results suggest that smoking was positively associated with increased SLE risk whereas light/moderate alcohol consumption was inversely associated with SLE risk, irrespective of the type of alcoholic beverage. Additional studies are warranted to confirm these findings. The Journal of Rheumatology

元の言語英語
ページ(範囲)1363-1370
ページ数8
ジャーナルJournal of Rheumatology
39
発行部数7
DOI
出版物ステータス出版済み - 7 2012

All Science Journal Classification (ASJC) codes

  • Rheumatology
  • Immunology and Allergy
  • Immunology

フィンガープリント Cigarette smoking, alcohol consumption, and risk of systemic lupus erythematosus: A case-control study in a Japanese population' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Kiyohara, C., Washio, M., Horiuchi, T., Asami, T., Ide, S., Atsumi, T., Kobashi, G., Tada, Y., Takahashi, H., Kodama, H., Akashi, K., Harada, M., Niiro, H., Tsukamoto, H., Hotokebuchi, T., Nagasawa, K., Ushiyama, O., Mori, M., Oura, A., ... Nagai, M. (2012). Cigarette smoking, alcohol consumption, and risk of systemic lupus erythematosus: A case-control study in a Japanese population. Journal of Rheumatology, 39(7), 1363-1370. https://doi.org/10.3899/jrheum.111609