Cip/Kip cyclin-dependent kinase inhibitors: Brakes of the cell cycle engine during development

Keiichi Nakayama, Keiko Nakayama

研究成果: ジャーナルへの寄稿評論記事

170 引用 (Scopus)

抄録

Precise control of cell-cycle progression is believed to be critical for normal development, while oncogenesis may be a direct result of its disturbance. Cell-cycle progression is regulated predominantly by a series of serine/threonine kinases, the cyclin-dependent kinases (CDKs). The activities of the CDKs are controlled by a variety of mechanisms, and a group of molecules that inhibit CDK activity, CDK inhibitors (CKIs), has recently become the focus of interest, particularly in the fields of development and tumorigenesis. To date, seven CKIs have been identified in mammals and categorized into two families, the Cip/Kip and Ink4 families. The Cip/Kip family is well conserved phylogenetically, suggesting that it is biologically important. Despite the structural and biochemical similarities among the Cip/Kip members, the phenotypes of knockout mice of each Cip/Kip member are surprisingly different, which suggests that the Cip/Kip CKIs have a variety of physiological functions. In this review, the biological roles of Cip/Kip CKIs in development and tumor suppression are discussed.

元の言語英語
ページ(範囲)1020-1029
ページ数10
ジャーナルBioEssays
20
発行部数12
DOI
出版物ステータス出版済み - 1 1 1998

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Cyclin-Dependent Kinases
Brakes
Cell Cycle
Cells
Engines
Carcinogenesis
Mammals
Protein-Serine-Threonine Kinases
Cell Cycle Checkpoints
Knockout Mice
Tumors
Phenotype
Molecules
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

これを引用

Cip/Kip cyclin-dependent kinase inhibitors : Brakes of the cell cycle engine during development. / Nakayama, Keiichi; Nakayama, Keiko.

:: BioEssays, 巻 20, 番号 12, 01.01.1998, p. 1020-1029.

研究成果: ジャーナルへの寄稿評論記事

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