Circadian disruption accelerates tumor growth and angio/stromagenesis through a wnt signaling pathway

Yoshihiro Yasuniwa, Hiroto Izumi, Ke Yong Wang, Shohei Shimajiri, Yasuyuki Sasaguri, Kazuaki Kawai, Hiroshi Kasai, Takashi Shimada, Koichi Miyake, Eiji Kashiwagi, Gen Hirano, Akihiko Kidani, Masaki Akiyama, Bin Han, Ying Wu, Ichiro Ieiri, Shun Higuchi, Kimitoshi Kohno

研究成果: Contribution to journalArticle査読

49 被引用数 (Scopus)

抄録

Epidemiologic studies show a high incidence of cancer in shift workers, suggesting a possible relationship between circadian rhythms and tumorigenesis. However, the precise molecular mechanism played by circadian rhythms in tumor progression is not known. To identify the possible mechanisms underlying tumor progression related to circadian rhythms, we set up nude mouse xenograft models. HeLa cells were injected in nude mice and nude mice were moved to two different cases, one case is exposed to a 24-hour light cycle (L/L), the other is a more ''normal'' 12-hour light/dark cycle (L/D). We found a significant increase in tumor volume in the L/L group compared with the L/D group. In addition, tumor microvessels and stroma were strongly increased in L/L mice. Although there was a hypervascularization in L/L tumors, there was no associated increase in the production of vascular endothelial cell growth factor (VEGF). DNA microarray analysis showed enhanced expression of WNT10A, and our subsequent study revealed that WNT10A stimulates the growth of both microvascular endothelial cells and fibroblasts in tumors from light-stressed mice, along with marked increases in angio/ stromagenesis. Only the tumor stroma stained positive for WNT10A and WNT10A is also highly expressed in keloid dermal fibroblasts but not in normal dermal fibroblasts indicated that WNT10A may be a novel angio/stromagenic growth factor. These findings suggest that circadian disruption induces the progression of malignant tumors via a Wnt signaling pathway. Copyright:

本文言語英語
論文番号e15330
ジャーナルPloS one
5
12
DOI
出版ステータス出版済み - 2010
外部発表はい

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • General

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