Circulating endothelial glycocalyx components as a predictive marker of coronary artery lesions in Kawasaki disease

Yuji Ohnishi, Hiroki Yasudo, Yasuo Suzuki, Takashi Furuta, Chie Matsuguma, Yoshihiro Azuma, Akiko Miyake, Seigo Okada, Kiyoshi Ichihara, Shoichi Ohga, Shunji Hasegawa

研究成果: ジャーナルへの寄稿記事

抄録

Background: Kawasaki disease (KD) is acute and self-limited vasculitis caused by unknown origin, and the critical complication in KD patients is coronary artery lesions (CALs). The endothelial glycocalyx is a network of membranes luminally covering the endothelium. This study aimed to evaluate the clinical utility of serum glycocalyx components as biomarkers of predicting the onset CALs in KD. Methods: Seventy subjects with complete type KD, 18 subjects as febrile control (FC), and 15 subjects as afebrile controls (AC) were enrolled. Medical, demographic, echocardiography, and laboratory data from the medical records were retrospectively analyzed. Serum syndecan-1 and hyaluronan levels prior to intravenous immunoglobulin (IVIG) therapy were measured at the acute phase, immediately after IVIG, the subacute phase, and the time of discharge at the convalescent phase. Results: Serum syndecan-1 and hyaluronan levels were higher in the KD group than in the AC and FC groups at all three phases. Further, these levels were compared between KD patients with and without the development of CALs. Serum syndecan-1 and hyaluronan levels at the acute phase were significantly elevated in KD patients with the CALs than in those without CALs. Serum hyaluronan, not syndecan-1, was determined as the most contributory parameter to predict CALs by a multiple logistic analysis. Conclusions: Circulating syndecan-1 and hyaluronan can be useful biomarkers to predict the development of CALs in KD.

元の言語英語
ページ(範囲)236-240
ページ数5
ジャーナルInternational Journal of Cardiology
292
DOI
出版物ステータス出版済み - 10 1 2019

Fingerprint

Glycocalyx
Mucocutaneous Lymph Node Syndrome
Syndecan-1
Coronary Vessels
Hyaluronic Acid
Serum
Intravenous Immunoglobulins
Fever
Biomarkers
Passive Immunization
Vasculitis
Endothelium
Medical Records
Echocardiography
Demography
Control Groups
Membranes

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

これを引用

Circulating endothelial glycocalyx components as a predictive marker of coronary artery lesions in Kawasaki disease. / Ohnishi, Yuji; Yasudo, Hiroki; Suzuki, Yasuo; Furuta, Takashi; Matsuguma, Chie; Azuma, Yoshihiro; Miyake, Akiko; Okada, Seigo; Ichihara, Kiyoshi; Ohga, Shoichi; Hasegawa, Shunji.

:: International Journal of Cardiology, 巻 292, 01.10.2019, p. 236-240.

研究成果: ジャーナルへの寄稿記事

Ohnishi, Y, Yasudo, H, Suzuki, Y, Furuta, T, Matsuguma, C, Azuma, Y, Miyake, A, Okada, S, Ichihara, K, Ohga, S & Hasegawa, S 2019, 'Circulating endothelial glycocalyx components as a predictive marker of coronary artery lesions in Kawasaki disease', International Journal of Cardiology, 巻. 292, pp. 236-240. https://doi.org/10.1016/j.ijcard.2019.05.045
Ohnishi, Yuji ; Yasudo, Hiroki ; Suzuki, Yasuo ; Furuta, Takashi ; Matsuguma, Chie ; Azuma, Yoshihiro ; Miyake, Akiko ; Okada, Seigo ; Ichihara, Kiyoshi ; Ohga, Shoichi ; Hasegawa, Shunji. / Circulating endothelial glycocalyx components as a predictive marker of coronary artery lesions in Kawasaki disease. :: International Journal of Cardiology. 2019 ; 巻 292. pp. 236-240.
@article{d63b7aab04e24e1c85ef503df1ffcfb7,
title = "Circulating endothelial glycocalyx components as a predictive marker of coronary artery lesions in Kawasaki disease",
abstract = "Background: Kawasaki disease (KD) is acute and self-limited vasculitis caused by unknown origin, and the critical complication in KD patients is coronary artery lesions (CALs). The endothelial glycocalyx is a network of membranes luminally covering the endothelium. This study aimed to evaluate the clinical utility of serum glycocalyx components as biomarkers of predicting the onset CALs in KD. Methods: Seventy subjects with complete type KD, 18 subjects as febrile control (FC), and 15 subjects as afebrile controls (AC) were enrolled. Medical, demographic, echocardiography, and laboratory data from the medical records were retrospectively analyzed. Serum syndecan-1 and hyaluronan levels prior to intravenous immunoglobulin (IVIG) therapy were measured at the acute phase, immediately after IVIG, the subacute phase, and the time of discharge at the convalescent phase. Results: Serum syndecan-1 and hyaluronan levels were higher in the KD group than in the AC and FC groups at all three phases. Further, these levels were compared between KD patients with and without the development of CALs. Serum syndecan-1 and hyaluronan levels at the acute phase were significantly elevated in KD patients with the CALs than in those without CALs. Serum hyaluronan, not syndecan-1, was determined as the most contributory parameter to predict CALs by a multiple logistic analysis. Conclusions: Circulating syndecan-1 and hyaluronan can be useful biomarkers to predict the development of CALs in KD.",
author = "Yuji Ohnishi and Hiroki Yasudo and Yasuo Suzuki and Takashi Furuta and Chie Matsuguma and Yoshihiro Azuma and Akiko Miyake and Seigo Okada and Kiyoshi Ichihara and Shoichi Ohga and Shunji Hasegawa",
year = "2019",
month = "10",
day = "1",
doi = "10.1016/j.ijcard.2019.05.045",
language = "English",
volume = "292",
pages = "236--240",
journal = "International Journal of Cardiology",
issn = "0167-5273",
publisher = "Elsevier Ireland Ltd",

}

TY - JOUR

T1 - Circulating endothelial glycocalyx components as a predictive marker of coronary artery lesions in Kawasaki disease

AU - Ohnishi, Yuji

AU - Yasudo, Hiroki

AU - Suzuki, Yasuo

AU - Furuta, Takashi

AU - Matsuguma, Chie

AU - Azuma, Yoshihiro

AU - Miyake, Akiko

AU - Okada, Seigo

AU - Ichihara, Kiyoshi

AU - Ohga, Shoichi

AU - Hasegawa, Shunji

PY - 2019/10/1

Y1 - 2019/10/1

N2 - Background: Kawasaki disease (KD) is acute and self-limited vasculitis caused by unknown origin, and the critical complication in KD patients is coronary artery lesions (CALs). The endothelial glycocalyx is a network of membranes luminally covering the endothelium. This study aimed to evaluate the clinical utility of serum glycocalyx components as biomarkers of predicting the onset CALs in KD. Methods: Seventy subjects with complete type KD, 18 subjects as febrile control (FC), and 15 subjects as afebrile controls (AC) were enrolled. Medical, demographic, echocardiography, and laboratory data from the medical records were retrospectively analyzed. Serum syndecan-1 and hyaluronan levels prior to intravenous immunoglobulin (IVIG) therapy were measured at the acute phase, immediately after IVIG, the subacute phase, and the time of discharge at the convalescent phase. Results: Serum syndecan-1 and hyaluronan levels were higher in the KD group than in the AC and FC groups at all three phases. Further, these levels were compared between KD patients with and without the development of CALs. Serum syndecan-1 and hyaluronan levels at the acute phase were significantly elevated in KD patients with the CALs than in those without CALs. Serum hyaluronan, not syndecan-1, was determined as the most contributory parameter to predict CALs by a multiple logistic analysis. Conclusions: Circulating syndecan-1 and hyaluronan can be useful biomarkers to predict the development of CALs in KD.

AB - Background: Kawasaki disease (KD) is acute and self-limited vasculitis caused by unknown origin, and the critical complication in KD patients is coronary artery lesions (CALs). The endothelial glycocalyx is a network of membranes luminally covering the endothelium. This study aimed to evaluate the clinical utility of serum glycocalyx components as biomarkers of predicting the onset CALs in KD. Methods: Seventy subjects with complete type KD, 18 subjects as febrile control (FC), and 15 subjects as afebrile controls (AC) were enrolled. Medical, demographic, echocardiography, and laboratory data from the medical records were retrospectively analyzed. Serum syndecan-1 and hyaluronan levels prior to intravenous immunoglobulin (IVIG) therapy were measured at the acute phase, immediately after IVIG, the subacute phase, and the time of discharge at the convalescent phase. Results: Serum syndecan-1 and hyaluronan levels were higher in the KD group than in the AC and FC groups at all three phases. Further, these levels were compared between KD patients with and without the development of CALs. Serum syndecan-1 and hyaluronan levels at the acute phase were significantly elevated in KD patients with the CALs than in those without CALs. Serum hyaluronan, not syndecan-1, was determined as the most contributory parameter to predict CALs by a multiple logistic analysis. Conclusions: Circulating syndecan-1 and hyaluronan can be useful biomarkers to predict the development of CALs in KD.

UR - http://www.scopus.com/inward/record.url?scp=85066979342&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85066979342&partnerID=8YFLogxK

U2 - 10.1016/j.ijcard.2019.05.045

DO - 10.1016/j.ijcard.2019.05.045

M3 - Article

AN - SCOPUS:85066979342

VL - 292

SP - 236

EP - 240

JO - International Journal of Cardiology

JF - International Journal of Cardiology

SN - 0167-5273

ER -