Circulating messenger for neuroprotection induced by molecular hydrogen

Mami Noda, Yuya Uemura, Yusuke Yoshii, Taichi Horita, Shota Takemi, Ichiro Sakata, Takafumi Sakai

研究成果: ジャーナルへの寄稿評論記事

1 引用 (Scopus)

抄録

Molecular hydrogen (H2) showed protection against various kinds of oxidative-stress-related diseases. First, it was reported that the mechanism of therapeutic effects of H2 was antioxidative effect due to inhibition of the most cytotoxic reactive oxygen species, hydroxy radical (• OH). However, after chronic administration of H2 in drinking water, oxidative-stress-induced nerve injury is significantly attenuated even in the absence of H2. It suggests indirect signaling of H2 and gastrointestinal tract is involved. Indirect effects of H2 could be tested by giving H2 water only before nerve injury, as preconditioning. For example, preconditioning of H2 for certain a period (∼7 days) in Parkinson’s disease model mice shows significant neuroprotection. As the mechanism of indirect effect, H2 in drinking water induces ghrelin production and release from the stomach via β1-adrenergic receptor stimulation. Released ghrelin circulates in the body, being transported across the blood–brain barrier, activates its receptor, growth-hormone secretagogue receptor. H2-induced upregulation of ghrelin mRNA is also shown in ghrelin-producing cell line, SG-1. These observations help with understanding the chronic effects of H2 and raise intriguing preventive and therapeutic options using H2.

元の言語英語
ページ(範囲)909-915
ページ数7
ジャーナルCanadian journal of physiology and pharmacology
97
発行部数10
DOI
出版物ステータス出版済み - 1 1 2019

Fingerprint

Ghrelin
Hydrogen
Drinking Water
Oxidative Stress
Ghrelin Receptor
Wounds and Injuries
Therapeutic Uses
Dehydration
Adrenergic Receptors
Parkinson Disease
Gastrointestinal Tract
Reactive Oxygen Species
Stomach
Up-Regulation
Cell Line
Messenger RNA
Neuroprotection
Water
Therapeutics

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

これを引用

Circulating messenger for neuroprotection induced by molecular hydrogen. / Noda, Mami; Uemura, Yuya; Yoshii, Yusuke; Horita, Taichi; Takemi, Shota; Sakata, Ichiro; Sakai, Takafumi.

:: Canadian journal of physiology and pharmacology, 巻 97, 番号 10, 01.01.2019, p. 909-915.

研究成果: ジャーナルへの寄稿評論記事

Noda, M, Uemura, Y, Yoshii, Y, Horita, T, Takemi, S, Sakata, I & Sakai, T 2019, 'Circulating messenger for neuroprotection induced by molecular hydrogen', Canadian journal of physiology and pharmacology, 巻. 97, 番号 10, pp. 909-915. https://doi.org/10.1139/cjpp-2019-0098
Noda, Mami ; Uemura, Yuya ; Yoshii, Yusuke ; Horita, Taichi ; Takemi, Shota ; Sakata, Ichiro ; Sakai, Takafumi. / Circulating messenger for neuroprotection induced by molecular hydrogen. :: Canadian journal of physiology and pharmacology. 2019 ; 巻 97, 番号 10. pp. 909-915.
@article{f6d84a5e141f436f83ae785106a0bba8,
title = "Circulating messenger for neuroprotection induced by molecular hydrogen",
abstract = "Molecular hydrogen (H2) showed protection against various kinds of oxidative-stress-related diseases. First, it was reported that the mechanism of therapeutic effects of H2 was antioxidative effect due to inhibition of the most cytotoxic reactive oxygen species, hydroxy radical (• OH). However, after chronic administration of H2 in drinking water, oxidative-stress-induced nerve injury is significantly attenuated even in the absence of H2. It suggests indirect signaling of H2 and gastrointestinal tract is involved. Indirect effects of H2 could be tested by giving H2 water only before nerve injury, as preconditioning. For example, preconditioning of H2 for certain a period (∼7 days) in Parkinson’s disease model mice shows significant neuroprotection. As the mechanism of indirect effect, H2 in drinking water induces ghrelin production and release from the stomach via β1-adrenergic receptor stimulation. Released ghrelin circulates in the body, being transported across the blood–brain barrier, activates its receptor, growth-hormone secretagogue receptor. H2-induced upregulation of ghrelin mRNA is also shown in ghrelin-producing cell line, SG-1. These observations help with understanding the chronic effects of H2 and raise intriguing preventive and therapeutic options using H2.",
author = "Mami Noda and Yuya Uemura and Yusuke Yoshii and Taichi Horita and Shota Takemi and Ichiro Sakata and Takafumi Sakai",
year = "2019",
month = "1",
day = "1",
doi = "10.1139/cjpp-2019-0098",
language = "English",
volume = "97",
pages = "909--915",
journal = "Canadian Journal of Physiology and Pharmacology",
issn = "0008-4212",
publisher = "National Research Council of Canada",
number = "10",

}

TY - JOUR

T1 - Circulating messenger for neuroprotection induced by molecular hydrogen

AU - Noda, Mami

AU - Uemura, Yuya

AU - Yoshii, Yusuke

AU - Horita, Taichi

AU - Takemi, Shota

AU - Sakata, Ichiro

AU - Sakai, Takafumi

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Molecular hydrogen (H2) showed protection against various kinds of oxidative-stress-related diseases. First, it was reported that the mechanism of therapeutic effects of H2 was antioxidative effect due to inhibition of the most cytotoxic reactive oxygen species, hydroxy radical (• OH). However, after chronic administration of H2 in drinking water, oxidative-stress-induced nerve injury is significantly attenuated even in the absence of H2. It suggests indirect signaling of H2 and gastrointestinal tract is involved. Indirect effects of H2 could be tested by giving H2 water only before nerve injury, as preconditioning. For example, preconditioning of H2 for certain a period (∼7 days) in Parkinson’s disease model mice shows significant neuroprotection. As the mechanism of indirect effect, H2 in drinking water induces ghrelin production and release from the stomach via β1-adrenergic receptor stimulation. Released ghrelin circulates in the body, being transported across the blood–brain barrier, activates its receptor, growth-hormone secretagogue receptor. H2-induced upregulation of ghrelin mRNA is also shown in ghrelin-producing cell line, SG-1. These observations help with understanding the chronic effects of H2 and raise intriguing preventive and therapeutic options using H2.

AB - Molecular hydrogen (H2) showed protection against various kinds of oxidative-stress-related diseases. First, it was reported that the mechanism of therapeutic effects of H2 was antioxidative effect due to inhibition of the most cytotoxic reactive oxygen species, hydroxy radical (• OH). However, after chronic administration of H2 in drinking water, oxidative-stress-induced nerve injury is significantly attenuated even in the absence of H2. It suggests indirect signaling of H2 and gastrointestinal tract is involved. Indirect effects of H2 could be tested by giving H2 water only before nerve injury, as preconditioning. For example, preconditioning of H2 for certain a period (∼7 days) in Parkinson’s disease model mice shows significant neuroprotection. As the mechanism of indirect effect, H2 in drinking water induces ghrelin production and release from the stomach via β1-adrenergic receptor stimulation. Released ghrelin circulates in the body, being transported across the blood–brain barrier, activates its receptor, growth-hormone secretagogue receptor. H2-induced upregulation of ghrelin mRNA is also shown in ghrelin-producing cell line, SG-1. These observations help with understanding the chronic effects of H2 and raise intriguing preventive and therapeutic options using H2.

UR - http://www.scopus.com/inward/record.url?scp=85072627636&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85072627636&partnerID=8YFLogxK

U2 - 10.1139/cjpp-2019-0098

DO - 10.1139/cjpp-2019-0098

M3 - Review article

C2 - 31100203

AN - SCOPUS:85072627636

VL - 97

SP - 909

EP - 915

JO - Canadian Journal of Physiology and Pharmacology

JF - Canadian Journal of Physiology and Pharmacology

SN - 0008-4212

IS - 10

ER -