Class switching from γ3 to γ2b in a murine pre-B cell line

Tani Yoshihiko, Sugiyama Haruo, Maeda Toyoki, Miyake Seigou, Oka Yoshihiro, Ogawa Hiroyasu, Komori Toshihisa, Soma Toshihiro, Kishimoto Susumu

研究成果: Contribution to journalArticle査読

抄録

Class switching from γ3 to γ2b production at pre-B cell stage was observed in an Abelson virus-transformed murine immature cell line that is able to perform VH to DJH recombinations followed by class switch recombinations. A series of Southern blotting experiments indicates that the class switching from γ3 to γ2b was mediated by the deletion mechanism of the intervening CH genes on the expressed chromosome and that the break points in the switch recombinations might be different from each other among six independent switching events from γ3 to γ2b. This in vitro switching system should provide us with much information on the mechanisms of class switch recombination.

本文言語英語
ページ(範囲)127-136
ページ数10
ジャーナルMolecular Immunology
25
2
DOI
出版ステータス出版済み - 2 1988
外部発表はい

All Science Journal Classification (ASJC) codes

  • 免疫学
  • 分子生物学

フィンガープリント

「Class switching from γ3 to γ2b in a murine pre-B cell line」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル