"Click chemistry" on polysaccharides: A convenient, general, and monitorable approach to develop β-1,3-glucans with various functional appendages

Teruaki Hasegawa, Munenori Numata, Kazuo Sakurai, Seiji Shinkai

研究成果: 会議への寄与タイプ学会誌査読

抄録

β-1,3-glucans having various functional appendages (β-lactoside, ferrocene, pyrene, and porphyrin) can be prepared in a convenient, quantitative, and regioselective manner through regioselective bromination/azidation on curdlan to afford 6-azido-6-deoxy-curdlan followed by chemo-selective [3+2]cycloadditions with various functional modules with a terminal alkyn. In addition to the aforementioned advantages, monitorablity is an additional advantage of this synthetic approach over the conventional direct modifications on polysaccharides, that is, the reaction can be easily monitored based on intensity of azido-peaks in in situ attenuated total reflection-infrared spectra. The resultant curdlan derivatives, especially that having lactoside-appendages, can interact with certain polynucleotides to form stable macromolecular complex that can bind to RCA120 (β-lactoside recognition lectin).

本文言語英語
ページ4895-4896
ページ数2
出版ステータス出版済み - 12月 1 2005
イベント54th SPSJ Symposium on Macromolecules - Yamagata, 日本
継続期間: 9月 20 20059月 22 2005

その他

その他54th SPSJ Symposium on Macromolecules
国/地域日本
CityYamagata
Period9/20/059/22/05

!!!All Science Journal Classification (ASJC) codes

  • 工学(全般)

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