'Click chemistry' on polysaccharides: A convenient, general, and monitorable approach to develop (1→3)-β-d-glucans with various functional appendages

Teruaki Hasegawa, Mariko Umeda, Munenori Numata, Chun Li, Ah Hyun Bae, Tomohisa Fujisawa, Shuichi Haraguchi, Kazuo Sakurai, Seiji Shinkai

研究成果: ジャーナルへの寄稿記事

107 引用 (Scopus)

抜粋

(1→3)-β-d-Glucans having various functional appendages (lactoside, ferrocene, pyrene, and porphyrin) can be prepared in an convenient, quantitative, and regioselective manner through regioselective bromination-azidation of curdlan to afford 6-azido-6-deoxycurdlan followed by chemoselective [3+2]-cycloadditions with various functional modules bearing a terminal alkyne group. The ability to monitor reaction conversions is an additional advantage of this synthetic approach over the conventional direct modifications on polysaccharides; the reaction can be readily monitored based on the intensity of azido peaks in the in situ attenuated total reflection infrared spectra.

元の言語英語
ページ(範囲)35-40
ページ数6
ジャーナルCarbohydrate Research
341
発行部数1
DOI
出版物ステータス出版済み - 1 16 2006

    フィンガープリント

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Organic Chemistry

これを引用