Clinical Analysis of en Bloc Resection for Advanced Temporal Bone Squamous Cell Carcinoma

Noritaka Komune, Daisuke Kuga, Satoshi Matsuo, Masaru Miyazaki, Teppei Noda, Kuniaki Sato, Takahiro Hongo, Kensuke Koike, Ryutaro Uchi, Ryunosuke Kogo, Nana Akagi Tsuchihashi, Shogo Masuda, Takashi Nakagawa

研究成果: Contribution to journalReview article査読

抄録

Objective En bloc and margin-negative surgical resection seems to offer the best prognosis for patients with temporal bone squamous cell carcinoma (TB-SCC). In this study, we summarize the outcomes of surgical cases of advanced TB-SCC (T3-T4) that were managed in two institutions, with an accompanying description of the surgical procedure that was utilized: modified subtotal temporal bone resection (STBR), which involves the en bloc removal of the temporal bone including or transecting the otic capsule. Design This is a case series study with chart review. Setting The study was conducted at two academic tertiary care medical centers. Participants Chart information was collected for all patients who underwent surgical resection of advanced TB-SCC between July 1998 and February 2019. The resulting dataset contained 43 patients with advanced TB-SCC who underwent en bloc resection during the review period. Tumor staging followed the modified Pittsburgh classification. Disease-specific survival (DSS) rates were calculated according to the Kaplan-Meier method. Main Outcome Measure This study shows disease-specific 5-year DSS rate. Results The 5-year DSS rate of the cases who underwent en bloc resection was 79.7%. En bloc lateral temporal bone resection was employed in a total of 25 cases (DSS: 79.0%). En bloc modified STBR was utilized in 18 cases (DSS: 81.7%). Conclusion En bloc margin-negative resection is a reliable treatment strategy for advanced TB-SCC. Modified STBR can be a treatment option for TB-SCC without marked posterior extension.

本文言語英語
ジャーナルJournal of Neurological Surgery, Part B: Skull Base
DOI
出版ステータス受理済み/印刷中 - 2021
外部発表はい

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

フィンガープリント 「Clinical Analysis of en Bloc Resection for Advanced Temporal Bone Squamous Cell Carcinoma」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル