Clinical and biological impact of cyclin-dependent kinase subunit 2 in esophageal squamous cell carcinoma

Yoshiaki Kita, Yuka Nishizono, Hiroshi Okumura, Yasuto Uchikado, Ken Sasaki, Masataka Matsumoto, Tetsuro Setoyama, Kiyonori Tanoue, Itaru Omoto, Shinichiro Mori, Tetsuhiro Owaki, Sumiya Ishigami, Hiroshi Nakagawa, Fumiaki Tanaka, Koshi Mimori, Masaki Mori, Shoji Natsugoe

研究成果: Contribution to journalArticle査読

15 被引用数 (Scopus)


Cyclin-dependent kinase subunit 2 (CKS2) is a cyclin-dependent kinase subunit (CKS) family member that participates in cell cycle regulation. Few studies have investigated its involvement in esophageal squamous cell carcinoma (ESCC). The aim of the present study was to assess the clinical significance of CKS2 in ESCC. We used immunohistochemistry to study the clinicopathologic significance of CKS2 protein expression in 121 patients with ESCC. Using real-time reverse transcriptase-polymerase chain reaction (RT-PCR), we examined the expression of CKS2 mRNA in tumors and the corresponding normal esophageal tissues that were obtained from 62 patients. Finally, siRNA-mediated attenuation of CKS2 expression was examined in vitro. CKS2 protein expression was significantly correlated with depth of tumor invasion, clinical stage, lymphatic invasion and distant metastasis (p=0.033, 0.028, 0.041 and 0.009, respectively). CKS2 mRNA expression was higher in cancer tissue than in corresponding normal tissue (p<0.001). Patients with positive-CKS2 protein.

ジャーナルOncology reports
出版ステータス出版済み - 5 2014

All Science Journal Classification (ASJC) codes

  • 腫瘍学
  • 癌研究


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