Clinical and computed tomography characteristics of non-small cell lung cancer with ALK gene rearrangement: Comparison with EGFR mutation and ALK/EGFR-negative lung cancer

Mio Mori, Hideyuki Hayashi, Minoru Fukuda, Sumihisa Honda, Takeshi Kitazaki, Kazuto Shigematsu, Naohiro Matsuyama, Mayumi Otsubo, Takeshi Nagayasu, Mikiko Hashisako, Kazuhiro Tabata, Masataka Uetani, Kazuto Ashizawa

研究成果: ジャーナルへの寄稿記事

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Background: The study was conducted to evaluate the clinical and computed tomography (CT) findings of non-small cell lung cancer (NSCLC) patients to distinguish between ALK gene rearrangement, EGFR mutation, and non-ALK/EGFR (no genetic abnormalities). Methods: We enrolled 201 patients with primary NSCLC who had undergone molecular testing for both ALK gene rearrangement and EGFR mutation. The clinical features and CT findings of the main lesion and associated pulmonary abnormalities were investigated. Results: Female gender (P = 0.0043 vs. non-ALK/EGFR), young age (P = 0.0156 vs. EGFR), and a light or never smoking history (P = 0.0039 vs. non-ALK/EGFR) were significant clinical characteristics of NSCLC with ALK gene rearrangement. The significant CT characteristics compared to NSCLC with EGFR mutation were a large mass (P = 0.0155), solid mass (P = 0.0048), and no air bronchogram (P = 0.0148). A central location (P = 0.0322) and lymphadenopathy (P = 0.0353) were also more frequently observed. Coexisting emphysema was significantly less frequent in NSCLC patients with ALK gene rearrangement (P = 0.0135) than non-ALK/EGFR. Conclusions: NSCLC with ALK gene rearrangement was more likely to develop in younger women with a light or never smoking history. The characteristic CT findings of NSCLC with ALK gene rearrangement were a large solid mass, less air bronchogram, a central location, and lymphadenopathy.

元の言語英語
ページ(範囲)872-879
ページ数8
ジャーナルThoracic Cancer
10
発行部数4
DOI
出版物ステータス出版済み - 4 2019

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Gene Rearrangement
Non-Small Cell Lung Carcinoma
Lung Neoplasms
Tomography
Mutation
Smoking
History
Air
Light
Emphysema
Lung

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine

これを引用

Clinical and computed tomography characteristics of non-small cell lung cancer with ALK gene rearrangement : Comparison with EGFR mutation and ALK/EGFR-negative lung cancer. / Mori, Mio; Hayashi, Hideyuki; Fukuda, Minoru; Honda, Sumihisa; Kitazaki, Takeshi; Shigematsu, Kazuto; Matsuyama, Naohiro; Otsubo, Mayumi; Nagayasu, Takeshi; Hashisako, Mikiko; Tabata, Kazuhiro; Uetani, Masataka; Ashizawa, Kazuto.

:: Thoracic Cancer, 巻 10, 番号 4, 04.2019, p. 872-879.

研究成果: ジャーナルへの寄稿記事

Mori, M, Hayashi, H, Fukuda, M, Honda, S, Kitazaki, T, Shigematsu, K, Matsuyama, N, Otsubo, M, Nagayasu, T, Hashisako, M, Tabata, K, Uetani, M & Ashizawa, K 2019, 'Clinical and computed tomography characteristics of non-small cell lung cancer with ALK gene rearrangement: Comparison with EGFR mutation and ALK/EGFR-negative lung cancer', Thoracic Cancer, 巻. 10, 番号 4, pp. 872-879. https://doi.org/10.1111/1759-7714.13017
Mori, Mio ; Hayashi, Hideyuki ; Fukuda, Minoru ; Honda, Sumihisa ; Kitazaki, Takeshi ; Shigematsu, Kazuto ; Matsuyama, Naohiro ; Otsubo, Mayumi ; Nagayasu, Takeshi ; Hashisako, Mikiko ; Tabata, Kazuhiro ; Uetani, Masataka ; Ashizawa, Kazuto. / Clinical and computed tomography characteristics of non-small cell lung cancer with ALK gene rearrangement : Comparison with EGFR mutation and ALK/EGFR-negative lung cancer. :: Thoracic Cancer. 2019 ; 巻 10, 番号 4. pp. 872-879.
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abstract = "Background: The study was conducted to evaluate the clinical and computed tomography (CT) findings of non-small cell lung cancer (NSCLC) patients to distinguish between ALK gene rearrangement, EGFR mutation, and non-ALK/EGFR (no genetic abnormalities). Methods: We enrolled 201 patients with primary NSCLC who had undergone molecular testing for both ALK gene rearrangement and EGFR mutation. The clinical features and CT findings of the main lesion and associated pulmonary abnormalities were investigated. Results: Female gender (P = 0.0043 vs. non-ALK/EGFR), young age (P = 0.0156 vs. EGFR), and a light or never smoking history (P = 0.0039 vs. non-ALK/EGFR) were significant clinical characteristics of NSCLC with ALK gene rearrangement. The significant CT characteristics compared to NSCLC with EGFR mutation were a large mass (P = 0.0155), solid mass (P = 0.0048), and no air bronchogram (P = 0.0148). A central location (P = 0.0322) and lymphadenopathy (P = 0.0353) were also more frequently observed. Coexisting emphysema was significantly less frequent in NSCLC patients with ALK gene rearrangement (P = 0.0135) than non-ALK/EGFR. Conclusions: NSCLC with ALK gene rearrangement was more likely to develop in younger women with a light or never smoking history. The characteristic CT findings of NSCLC with ALK gene rearrangement were a large solid mass, less air bronchogram, a central location, and lymphadenopathy.",
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T1 - Clinical and computed tomography characteristics of non-small cell lung cancer with ALK gene rearrangement

T2 - Comparison with EGFR mutation and ALK/EGFR-negative lung cancer

AU - Mori, Mio

AU - Hayashi, Hideyuki

AU - Fukuda, Minoru

AU - Honda, Sumihisa

AU - Kitazaki, Takeshi

AU - Shigematsu, Kazuto

AU - Matsuyama, Naohiro

AU - Otsubo, Mayumi

AU - Nagayasu, Takeshi

AU - Hashisako, Mikiko

AU - Tabata, Kazuhiro

AU - Uetani, Masataka

AU - Ashizawa, Kazuto

PY - 2019/4

Y1 - 2019/4

N2 - Background: The study was conducted to evaluate the clinical and computed tomography (CT) findings of non-small cell lung cancer (NSCLC) patients to distinguish between ALK gene rearrangement, EGFR mutation, and non-ALK/EGFR (no genetic abnormalities). Methods: We enrolled 201 patients with primary NSCLC who had undergone molecular testing for both ALK gene rearrangement and EGFR mutation. The clinical features and CT findings of the main lesion and associated pulmonary abnormalities were investigated. Results: Female gender (P = 0.0043 vs. non-ALK/EGFR), young age (P = 0.0156 vs. EGFR), and a light or never smoking history (P = 0.0039 vs. non-ALK/EGFR) were significant clinical characteristics of NSCLC with ALK gene rearrangement. The significant CT characteristics compared to NSCLC with EGFR mutation were a large mass (P = 0.0155), solid mass (P = 0.0048), and no air bronchogram (P = 0.0148). A central location (P = 0.0322) and lymphadenopathy (P = 0.0353) were also more frequently observed. Coexisting emphysema was significantly less frequent in NSCLC patients with ALK gene rearrangement (P = 0.0135) than non-ALK/EGFR. Conclusions: NSCLC with ALK gene rearrangement was more likely to develop in younger women with a light or never smoking history. The characteristic CT findings of NSCLC with ALK gene rearrangement were a large solid mass, less air bronchogram, a central location, and lymphadenopathy.

AB - Background: The study was conducted to evaluate the clinical and computed tomography (CT) findings of non-small cell lung cancer (NSCLC) patients to distinguish between ALK gene rearrangement, EGFR mutation, and non-ALK/EGFR (no genetic abnormalities). Methods: We enrolled 201 patients with primary NSCLC who had undergone molecular testing for both ALK gene rearrangement and EGFR mutation. The clinical features and CT findings of the main lesion and associated pulmonary abnormalities were investigated. Results: Female gender (P = 0.0043 vs. non-ALK/EGFR), young age (P = 0.0156 vs. EGFR), and a light or never smoking history (P = 0.0039 vs. non-ALK/EGFR) were significant clinical characteristics of NSCLC with ALK gene rearrangement. The significant CT characteristics compared to NSCLC with EGFR mutation were a large mass (P = 0.0155), solid mass (P = 0.0048), and no air bronchogram (P = 0.0148). A central location (P = 0.0322) and lymphadenopathy (P = 0.0353) were also more frequently observed. Coexisting emphysema was significantly less frequent in NSCLC patients with ALK gene rearrangement (P = 0.0135) than non-ALK/EGFR. Conclusions: NSCLC with ALK gene rearrangement was more likely to develop in younger women with a light or never smoking history. The characteristic CT findings of NSCLC with ALK gene rearrangement were a large solid mass, less air bronchogram, a central location, and lymphadenopathy.

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U2 - 10.1111/1759-7714.13017

DO - 10.1111/1759-7714.13017

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VL - 10

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JO - Thoracic Cancer

JF - Thoracic Cancer

SN - 1759-7706

IS - 4

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