Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma

Yasuhiro Fujisawa, Shusuke Yoshikawa, Akane Minagawa, Tatsuya Takenouchi, Kenji Yokota, Uchi Hiroshi, Naoki Noma, Yasuhiro Nakamura, Jun Asai, Junji Kato, Susumu Fujiwara, Satoshi Fukushima, Jiro Uehara, Toshihiko Hoashi, Tatsuya Kaji, Taku Fujimura, Kenjiro Namikawa, Manabu Yoshioka, Naoki Murao, Dai Ogata & 13 others Kanako Matsuyama, Naohito Hatta, Yoshitsugu Shibayama, Toshiharu Fujiyama, Masashi Ishikawa, Daisuke Yamada, Akiko Kishi, Yoshiyuki Nakamura, Takatoshi Shimiauchi, Kazuyasu Fujii, Manabu Fujimoto, Hironobu Ihn, Norito Katoh

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

抄録

Background: The incidence of melanoma among those of an Asian ethnicity is lower than in Caucasians; few large-scale Asian studies that include follow-up data have been reported. Objectives: To investigate the clinical characteristics of Japanese patients with melanoma and to evaluate the prognostic factors. Methods: Detailed patient information was collected from the database of Japanese Melanoma Study Group of the Japanese Skin Cancer Society. The American Joint Committee on Cancer seventh Edition system was used for TNM classification. The Kaplan-Meier method and Cox proportional hazards model were used to estimate the impact of clinical and histological parameters on disease-specific survival in patients with invasive melanoma. Results: In total, 4594 patients were included in this analysis. The most common clinical type was acral lentiginous melanoma (40.4%) followed by superficial spreading melanoma (20.5%), nodular melanoma (10.0%), mucosal melanoma (9.5%), and lentigo maligna melanoma (8.1%). The 5-year disease-specific survival for each stage was as follows: IA = 98.0%, IB = 93.9%, IIA = 94.8%, IIB = 82.4%, IIC = 71.8%, IIIA = 75.0%, IIIB = 61.3%, IIIC = 41.7%, and IV = 17.7%. Although multivariate analysis showed that clinical classifications were not associated with survival across all stages, acral type was an independent poor prognostic factor in stage IIIA. Conclusions: Our study revealed the characteristics of melanoma in the Japanese population. The 5-year disease-specific survival of each stage showed a similar trend to that of Caucasians. While clinical classification was not associated with survival in any stages, acral type was associated with poor survival in stage IIIA. Our result might indicate the aggressiveness of acral type in certain populations.

元の言語英語
ページ(範囲)2146-2156
ページ数11
ジャーナルCancer Medicine
8
発行部数5
DOI
出版物ステータス出版済み - 5 1 2019

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Survival Analysis
Melanoma
Survival
Extremities
Hutchinson's Melanotic Freckle
Neoplasm Staging
Skin Neoplasms
Proportional Hazards Models
Population
Multivariate Analysis
Databases
Incidence

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

これを引用

Fujisawa, Y., Yoshikawa, S., Minagawa, A., Takenouchi, T., Yokota, K., Hiroshi, U., ... Katoh, N. (2019). Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma. Cancer Medicine, 8(5), 2146-2156. https://doi.org/10.1002/cam4.2110

Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma. / Fujisawa, Yasuhiro; Yoshikawa, Shusuke; Minagawa, Akane; Takenouchi, Tatsuya; Yokota, Kenji; Hiroshi, Uchi; Noma, Naoki; Nakamura, Yasuhiro; Asai, Jun; Kato, Junji; Fujiwara, Susumu; Fukushima, Satoshi; Uehara, Jiro; Hoashi, Toshihiko; Kaji, Tatsuya; Fujimura, Taku; Namikawa, Kenjiro; Yoshioka, Manabu; Murao, Naoki; Ogata, Dai; Matsuyama, Kanako; Hatta, Naohito; Shibayama, Yoshitsugu; Fujiyama, Toshiharu; Ishikawa, Masashi; Yamada, Daisuke; Kishi, Akiko; Nakamura, Yoshiyuki; Shimiauchi, Takatoshi; Fujii, Kazuyasu; Fujimoto, Manabu; Ihn, Hironobu; Katoh, Norito.

:: Cancer Medicine, 巻 8, 番号 5, 01.05.2019, p. 2146-2156.

研究成果: ジャーナルへの寄稿記事

Fujisawa, Y, Yoshikawa, S, Minagawa, A, Takenouchi, T, Yokota, K, Hiroshi, U, Noma, N, Nakamura, Y, Asai, J, Kato, J, Fujiwara, S, Fukushima, S, Uehara, J, Hoashi, T, Kaji, T, Fujimura, T, Namikawa, K, Yoshioka, M, Murao, N, Ogata, D, Matsuyama, K, Hatta, N, Shibayama, Y, Fujiyama, T, Ishikawa, M, Yamada, D, Kishi, A, Nakamura, Y, Shimiauchi, T, Fujii, K, Fujimoto, M, Ihn, H & Katoh, N 2019, 'Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma', Cancer Medicine, 巻. 8, 番号 5, pp. 2146-2156. https://doi.org/10.1002/cam4.2110
Fujisawa Y, Yoshikawa S, Minagawa A, Takenouchi T, Yokota K, Hiroshi U その他. Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma. Cancer Medicine. 2019 5 1;8(5):2146-2156. https://doi.org/10.1002/cam4.2110
Fujisawa, Yasuhiro ; Yoshikawa, Shusuke ; Minagawa, Akane ; Takenouchi, Tatsuya ; Yokota, Kenji ; Hiroshi, Uchi ; Noma, Naoki ; Nakamura, Yasuhiro ; Asai, Jun ; Kato, Junji ; Fujiwara, Susumu ; Fukushima, Satoshi ; Uehara, Jiro ; Hoashi, Toshihiko ; Kaji, Tatsuya ; Fujimura, Taku ; Namikawa, Kenjiro ; Yoshioka, Manabu ; Murao, Naoki ; Ogata, Dai ; Matsuyama, Kanako ; Hatta, Naohito ; Shibayama, Yoshitsugu ; Fujiyama, Toshiharu ; Ishikawa, Masashi ; Yamada, Daisuke ; Kishi, Akiko ; Nakamura, Yoshiyuki ; Shimiauchi, Takatoshi ; Fujii, Kazuyasu ; Fujimoto, Manabu ; Ihn, Hironobu ; Katoh, Norito. / Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma. :: Cancer Medicine. 2019 ; 巻 8, 番号 5. pp. 2146-2156.
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title = "Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma",
abstract = "Background: The incidence of melanoma among those of an Asian ethnicity is lower than in Caucasians; few large-scale Asian studies that include follow-up data have been reported. Objectives: To investigate the clinical characteristics of Japanese patients with melanoma and to evaluate the prognostic factors. Methods: Detailed patient information was collected from the database of Japanese Melanoma Study Group of the Japanese Skin Cancer Society. The American Joint Committee on Cancer seventh Edition system was used for TNM classification. The Kaplan-Meier method and Cox proportional hazards model were used to estimate the impact of clinical and histological parameters on disease-specific survival in patients with invasive melanoma. Results: In total, 4594 patients were included in this analysis. The most common clinical type was acral lentiginous melanoma (40.4{\%}) followed by superficial spreading melanoma (20.5{\%}), nodular melanoma (10.0{\%}), mucosal melanoma (9.5{\%}), and lentigo maligna melanoma (8.1{\%}). The 5-year disease-specific survival for each stage was as follows: IA = 98.0{\%}, IB = 93.9{\%}, IIA = 94.8{\%}, IIB = 82.4{\%}, IIC = 71.8{\%}, IIIA = 75.0{\%}, IIIB = 61.3{\%}, IIIC = 41.7{\%}, and IV = 17.7{\%}. Although multivariate analysis showed that clinical classifications were not associated with survival across all stages, acral type was an independent poor prognostic factor in stage IIIA. Conclusions: Our study revealed the characteristics of melanoma in the Japanese population. The 5-year disease-specific survival of each stage showed a similar trend to that of Caucasians. While clinical classification was not associated with survival in any stages, acral type was associated with poor survival in stage IIIA. Our result might indicate the aggressiveness of acral type in certain populations.",
author = "Yasuhiro Fujisawa and Shusuke Yoshikawa and Akane Minagawa and Tatsuya Takenouchi and Kenji Yokota and Uchi Hiroshi and Naoki Noma and Yasuhiro Nakamura and Jun Asai and Junji Kato and Susumu Fujiwara and Satoshi Fukushima and Jiro Uehara and Toshihiko Hoashi and Tatsuya Kaji and Taku Fujimura and Kenjiro Namikawa and Manabu Yoshioka and Naoki Murao and Dai Ogata and Kanako Matsuyama and Naohito Hatta and Yoshitsugu Shibayama and Toshiharu Fujiyama and Masashi Ishikawa and Daisuke Yamada and Akiko Kishi and Yoshiyuki Nakamura and Takatoshi Shimiauchi and Kazuyasu Fujii and Manabu Fujimoto and Hironobu Ihn and Norito Katoh",
year = "2019",
month = "5",
day = "1",
doi = "10.1002/cam4.2110",
language = "English",
volume = "8",
pages = "2146--2156",
journal = "Cancer Medicine",
issn = "2045-7634",
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TY - JOUR

T1 - Clinical and histopathological characteristics and survival analysis of 4594 Japanese patients with melanoma

AU - Fujisawa, Yasuhiro

AU - Yoshikawa, Shusuke

AU - Minagawa, Akane

AU - Takenouchi, Tatsuya

AU - Yokota, Kenji

AU - Hiroshi, Uchi

AU - Noma, Naoki

AU - Nakamura, Yasuhiro

AU - Asai, Jun

AU - Kato, Junji

AU - Fujiwara, Susumu

AU - Fukushima, Satoshi

AU - Uehara, Jiro

AU - Hoashi, Toshihiko

AU - Kaji, Tatsuya

AU - Fujimura, Taku

AU - Namikawa, Kenjiro

AU - Yoshioka, Manabu

AU - Murao, Naoki

AU - Ogata, Dai

AU - Matsuyama, Kanako

AU - Hatta, Naohito

AU - Shibayama, Yoshitsugu

AU - Fujiyama, Toshiharu

AU - Ishikawa, Masashi

AU - Yamada, Daisuke

AU - Kishi, Akiko

AU - Nakamura, Yoshiyuki

AU - Shimiauchi, Takatoshi

AU - Fujii, Kazuyasu

AU - Fujimoto, Manabu

AU - Ihn, Hironobu

AU - Katoh, Norito

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Background: The incidence of melanoma among those of an Asian ethnicity is lower than in Caucasians; few large-scale Asian studies that include follow-up data have been reported. Objectives: To investigate the clinical characteristics of Japanese patients with melanoma and to evaluate the prognostic factors. Methods: Detailed patient information was collected from the database of Japanese Melanoma Study Group of the Japanese Skin Cancer Society. The American Joint Committee on Cancer seventh Edition system was used for TNM classification. The Kaplan-Meier method and Cox proportional hazards model were used to estimate the impact of clinical and histological parameters on disease-specific survival in patients with invasive melanoma. Results: In total, 4594 patients were included in this analysis. The most common clinical type was acral lentiginous melanoma (40.4%) followed by superficial spreading melanoma (20.5%), nodular melanoma (10.0%), mucosal melanoma (9.5%), and lentigo maligna melanoma (8.1%). The 5-year disease-specific survival for each stage was as follows: IA = 98.0%, IB = 93.9%, IIA = 94.8%, IIB = 82.4%, IIC = 71.8%, IIIA = 75.0%, IIIB = 61.3%, IIIC = 41.7%, and IV = 17.7%. Although multivariate analysis showed that clinical classifications were not associated with survival across all stages, acral type was an independent poor prognostic factor in stage IIIA. Conclusions: Our study revealed the characteristics of melanoma in the Japanese population. The 5-year disease-specific survival of each stage showed a similar trend to that of Caucasians. While clinical classification was not associated with survival in any stages, acral type was associated with poor survival in stage IIIA. Our result might indicate the aggressiveness of acral type in certain populations.

AB - Background: The incidence of melanoma among those of an Asian ethnicity is lower than in Caucasians; few large-scale Asian studies that include follow-up data have been reported. Objectives: To investigate the clinical characteristics of Japanese patients with melanoma and to evaluate the prognostic factors. Methods: Detailed patient information was collected from the database of Japanese Melanoma Study Group of the Japanese Skin Cancer Society. The American Joint Committee on Cancer seventh Edition system was used for TNM classification. The Kaplan-Meier method and Cox proportional hazards model were used to estimate the impact of clinical and histological parameters on disease-specific survival in patients with invasive melanoma. Results: In total, 4594 patients were included in this analysis. The most common clinical type was acral lentiginous melanoma (40.4%) followed by superficial spreading melanoma (20.5%), nodular melanoma (10.0%), mucosal melanoma (9.5%), and lentigo maligna melanoma (8.1%). The 5-year disease-specific survival for each stage was as follows: IA = 98.0%, IB = 93.9%, IIA = 94.8%, IIB = 82.4%, IIC = 71.8%, IIIA = 75.0%, IIIB = 61.3%, IIIC = 41.7%, and IV = 17.7%. Although multivariate analysis showed that clinical classifications were not associated with survival across all stages, acral type was an independent poor prognostic factor in stage IIIA. Conclusions: Our study revealed the characteristics of melanoma in the Japanese population. The 5-year disease-specific survival of each stage showed a similar trend to that of Caucasians. While clinical classification was not associated with survival in any stages, acral type was associated with poor survival in stage IIIA. Our result might indicate the aggressiveness of acral type in certain populations.

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U2 - 10.1002/cam4.2110

DO - 10.1002/cam4.2110

M3 - Article

VL - 8

SP - 2146

EP - 2156

JO - Cancer Medicine

JF - Cancer Medicine

SN - 2045-7634

IS - 5

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