Clinical and Prognostic Significance of the Epithelial–Mesenchymal Transition in Stage IA Lung Adenocarcinoma: A Propensity Score–Matched Analysis

Taichi Matsubara, Tetsuzo Tagawa, Kazuki Takada, G. Toyokawa, Mototsugu Shimokawa, Yuka Kozuma, Takaki Akamine, A. Haro, Atsushi Osoegawa, Masaki Mori

研究成果: ジャーナルへの寄稿記事

抄録

Background: The epithelial–mesenchymal transition (EMT) describes the process through which cells lose epithelial characteristics and gain a mesenchymal phenotype. The EMT contributes to tumor invasion and cancer progression, and is associated with metastasis and poor survival of patients with non–small-cell lung cancer. However, little is known about the relationships between the EMT and the clinicopathologic characteristics of patients with stage IA lung adenocarcinoma. Patients and Methods: We conducted immunohistochemical analysis of the expression of the EMT markers E-cadherin and vimentin of specimens acquired from 183 consecutive patients with stage IA lung adenocarcinoma. The clinicopathologic significance of the association of the EMT status with E-cadherin and vimentin expression was analyzed after propensity score matching. Results: E-cadherin and vimentin were detected in 68.3% and 18.6% of stage IA lung adenocarcinomas, respectively. The presence of cells with EMT conversion was associated with older patient age. A propensity score–matched cohort (128 patients) was used for further analyses. Computed tomography revealed that tumors with EMT conversion showed solid-dominant nodules compared to those without conversion. Survival analysis after propensity score matching showed that the EMT correlated with poor disease-free survival (hazard ratio = 2.57, P = .0451) and overall survival (hazard ratio = 4.23, P = .0471). Multivariate analysis revealed that the EMT was an independent predictor of shorter disease-free survival. Conclusion: The EMT was a significant predictor of poor prognosis of patients with stage IA lung adenocarcinoma. The EMT status may serve as an indicator for administering adjuvant therapy. We aimed to analyze the clinical significance of the epithelial–mesenchymal transition (EMT) in stage IA lung adenocarcinoma. Tumors with the EMT phenotype were identified in 43.1% of patients with a high ratio of consolidation to tumor diameter. Propensity score matching indicated a significant association of the EMT with shorter survival.

元の言語英語
ページ(範囲)e504-e513
ジャーナルClinical Lung Cancer
20
発行部数4
DOI
出版物ステータス出版済み - 7 2019

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Propensity Score
Vimentin
Cadherins
Neoplasms
Disease-Free Survival
Survival
Phenotype
Adenocarcinoma of lung
Survival Analysis
Non-Small Cell Lung Carcinoma
Multivariate Analysis
Epithelial Cells
Tomography
Neoplasm Metastasis
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine
  • Cancer Research

これを引用

Clinical and Prognostic Significance of the Epithelial–Mesenchymal Transition in Stage IA Lung Adenocarcinoma : A Propensity Score–Matched Analysis. / Matsubara, Taichi; Tagawa, Tetsuzo; Takada, Kazuki; Toyokawa, G.; Shimokawa, Mototsugu; Kozuma, Yuka; Akamine, Takaki; Haro, A.; Osoegawa, Atsushi; Mori, Masaki.

:: Clinical Lung Cancer, 巻 20, 番号 4, 07.2019, p. e504-e513.

研究成果: ジャーナルへの寄稿記事

Matsubara, Taichi ; Tagawa, Tetsuzo ; Takada, Kazuki ; Toyokawa, G. ; Shimokawa, Mototsugu ; Kozuma, Yuka ; Akamine, Takaki ; Haro, A. ; Osoegawa, Atsushi ; Mori, Masaki. / Clinical and Prognostic Significance of the Epithelial–Mesenchymal Transition in Stage IA Lung Adenocarcinoma : A Propensity Score–Matched Analysis. :: Clinical Lung Cancer. 2019 ; 巻 20, 番号 4. pp. e504-e513.
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title = "Clinical and Prognostic Significance of the Epithelial–Mesenchymal Transition in Stage IA Lung Adenocarcinoma: A Propensity Score–Matched Analysis",
abstract = "Background: The epithelial–mesenchymal transition (EMT) describes the process through which cells lose epithelial characteristics and gain a mesenchymal phenotype. The EMT contributes to tumor invasion and cancer progression, and is associated with metastasis and poor survival of patients with non–small-cell lung cancer. However, little is known about the relationships between the EMT and the clinicopathologic characteristics of patients with stage IA lung adenocarcinoma. Patients and Methods: We conducted immunohistochemical analysis of the expression of the EMT markers E-cadherin and vimentin of specimens acquired from 183 consecutive patients with stage IA lung adenocarcinoma. The clinicopathologic significance of the association of the EMT status with E-cadherin and vimentin expression was analyzed after propensity score matching. Results: E-cadherin and vimentin were detected in 68.3{\%} and 18.6{\%} of stage IA lung adenocarcinomas, respectively. The presence of cells with EMT conversion was associated with older patient age. A propensity score–matched cohort (128 patients) was used for further analyses. Computed tomography revealed that tumors with EMT conversion showed solid-dominant nodules compared to those without conversion. Survival analysis after propensity score matching showed that the EMT correlated with poor disease-free survival (hazard ratio = 2.57, P = .0451) and overall survival (hazard ratio = 4.23, P = .0471). Multivariate analysis revealed that the EMT was an independent predictor of shorter disease-free survival. Conclusion: The EMT was a significant predictor of poor prognosis of patients with stage IA lung adenocarcinoma. The EMT status may serve as an indicator for administering adjuvant therapy. We aimed to analyze the clinical significance of the epithelial–mesenchymal transition (EMT) in stage IA lung adenocarcinoma. Tumors with the EMT phenotype were identified in 43.1{\%} of patients with a high ratio of consolidation to tumor diameter. Propensity score matching indicated a significant association of the EMT with shorter survival.",
author = "Taichi Matsubara and Tetsuzo Tagawa and Kazuki Takada and G. Toyokawa and Mototsugu Shimokawa and Yuka Kozuma and Takaki Akamine and A. Haro and Atsushi Osoegawa and Masaki Mori",
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TY - JOUR

T1 - Clinical and Prognostic Significance of the Epithelial–Mesenchymal Transition in Stage IA Lung Adenocarcinoma

T2 - A Propensity Score–Matched Analysis

AU - Matsubara, Taichi

AU - Tagawa, Tetsuzo

AU - Takada, Kazuki

AU - Toyokawa, G.

AU - Shimokawa, Mototsugu

AU - Kozuma, Yuka

AU - Akamine, Takaki

AU - Haro, A.

AU - Osoegawa, Atsushi

AU - Mori, Masaki

PY - 2019/7

Y1 - 2019/7

N2 - Background: The epithelial–mesenchymal transition (EMT) describes the process through which cells lose epithelial characteristics and gain a mesenchymal phenotype. The EMT contributes to tumor invasion and cancer progression, and is associated with metastasis and poor survival of patients with non–small-cell lung cancer. However, little is known about the relationships between the EMT and the clinicopathologic characteristics of patients with stage IA lung adenocarcinoma. Patients and Methods: We conducted immunohistochemical analysis of the expression of the EMT markers E-cadherin and vimentin of specimens acquired from 183 consecutive patients with stage IA lung adenocarcinoma. The clinicopathologic significance of the association of the EMT status with E-cadherin and vimentin expression was analyzed after propensity score matching. Results: E-cadherin and vimentin were detected in 68.3% and 18.6% of stage IA lung adenocarcinomas, respectively. The presence of cells with EMT conversion was associated with older patient age. A propensity score–matched cohort (128 patients) was used for further analyses. Computed tomography revealed that tumors with EMT conversion showed solid-dominant nodules compared to those without conversion. Survival analysis after propensity score matching showed that the EMT correlated with poor disease-free survival (hazard ratio = 2.57, P = .0451) and overall survival (hazard ratio = 4.23, P = .0471). Multivariate analysis revealed that the EMT was an independent predictor of shorter disease-free survival. Conclusion: The EMT was a significant predictor of poor prognosis of patients with stage IA lung adenocarcinoma. The EMT status may serve as an indicator for administering adjuvant therapy. We aimed to analyze the clinical significance of the epithelial–mesenchymal transition (EMT) in stage IA lung adenocarcinoma. Tumors with the EMT phenotype were identified in 43.1% of patients with a high ratio of consolidation to tumor diameter. Propensity score matching indicated a significant association of the EMT with shorter survival.

AB - Background: The epithelial–mesenchymal transition (EMT) describes the process through which cells lose epithelial characteristics and gain a mesenchymal phenotype. The EMT contributes to tumor invasion and cancer progression, and is associated with metastasis and poor survival of patients with non–small-cell lung cancer. However, little is known about the relationships between the EMT and the clinicopathologic characteristics of patients with stage IA lung adenocarcinoma. Patients and Methods: We conducted immunohistochemical analysis of the expression of the EMT markers E-cadherin and vimentin of specimens acquired from 183 consecutive patients with stage IA lung adenocarcinoma. The clinicopathologic significance of the association of the EMT status with E-cadherin and vimentin expression was analyzed after propensity score matching. Results: E-cadherin and vimentin were detected in 68.3% and 18.6% of stage IA lung adenocarcinomas, respectively. The presence of cells with EMT conversion was associated with older patient age. A propensity score–matched cohort (128 patients) was used for further analyses. Computed tomography revealed that tumors with EMT conversion showed solid-dominant nodules compared to those without conversion. Survival analysis after propensity score matching showed that the EMT correlated with poor disease-free survival (hazard ratio = 2.57, P = .0451) and overall survival (hazard ratio = 4.23, P = .0471). Multivariate analysis revealed that the EMT was an independent predictor of shorter disease-free survival. Conclusion: The EMT was a significant predictor of poor prognosis of patients with stage IA lung adenocarcinoma. The EMT status may serve as an indicator for administering adjuvant therapy. We aimed to analyze the clinical significance of the epithelial–mesenchymal transition (EMT) in stage IA lung adenocarcinoma. Tumors with the EMT phenotype were identified in 43.1% of patients with a high ratio of consolidation to tumor diameter. Propensity score matching indicated a significant association of the EMT with shorter survival.

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U2 - 10.1016/j.cllc.2019.04.006

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