TY - JOUR
T1 - Clinical characteristics and long-term prognosis of patients with variant angina. A comparative study between western and Japanese populations
AU - Shimokawa, Hiroaki
AU - Nagasawa, Kazushige
AU - Irie, Takashi
AU - Egashira, Shogo
AU - Egashira, Kensuke
AU - Sagara, Tomohiko
AU - Kikuchi, Yutaka
AU - Nakamura, Motoomi
N1 - Funding Information:
This study was made feasible by the generous cooperation of Dr. S. Sever, University of Pisa, Dr. D.D. Waters, Montreal Heart Institute, and Dr. D.B. Mark, Duke University, who kindly provided data concerning clinical characteristics and long-term prognosis of their patients with variant angina. We thank the American Heart Association and the Journal of American Cardiology for permissions to reproduce the data. The authors are also indebted to Dr. P.C. O’Brien and Mrs. C. Chu, Department of Medical Statistics and Epidemiology of the Mayo Clinic and Foundation, for kind cooperation, and M. Ohara of Kyushu University for comments on the manuscript. This work was supported in part by the Japan Research Foundation for Clinical Pharmacology and the Japan Foundation for Health Sciences.
PY - 1988/3
Y1 - 1988/3
N2 - To determine the factors influencing the prognosis of variant angina, the clinical characteristics and long-term prognosis of 158 consecutive Japanese patients were examined and compared with those in previous major western studies (Pisa, Montreal, and Duke studies). The Japanese patients were characterized by relatively low prevalences of coronary risk factors, significant coronary stenoses and previous myocardial infarction. Survival and survival without myocardial infarction for the entire group or for the subpopulation with significant coronary artery disease were significantly better in the Japanese population than in the western populations; however, in the subpopulation without significant coronary artery disease, the prognosis was excellent in all four studies. If the prevalence of coronary artery disease was corrected for the Japanese population, there would be no difference in the prognosis between the Japanese and the western populations. It is concluded: (1) the overall prognosis of variant angina may be better in Japanese patients, and (2) coronary artery disease appears to be the strongest prognostic factor for assessing the differences in the prognosis between the Japanese and the western populations.
AB - To determine the factors influencing the prognosis of variant angina, the clinical characteristics and long-term prognosis of 158 consecutive Japanese patients were examined and compared with those in previous major western studies (Pisa, Montreal, and Duke studies). The Japanese patients were characterized by relatively low prevalences of coronary risk factors, significant coronary stenoses and previous myocardial infarction. Survival and survival without myocardial infarction for the entire group or for the subpopulation with significant coronary artery disease were significantly better in the Japanese population than in the western populations; however, in the subpopulation without significant coronary artery disease, the prognosis was excellent in all four studies. If the prevalence of coronary artery disease was corrected for the Japanese population, there would be no difference in the prognosis between the Japanese and the western populations. It is concluded: (1) the overall prognosis of variant angina may be better in Japanese patients, and (2) coronary artery disease appears to be the strongest prognostic factor for assessing the differences in the prognosis between the Japanese and the western populations.
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U2 - 10.1016/0167-5273(88)90052-6
DO - 10.1016/0167-5273(88)90052-6
M3 - Article
C2 - 3129375
AN - SCOPUS:0023837519
VL - 18
SP - 331
EP - 349
JO - International Journal of Cardiology
JF - International Journal of Cardiology
SN - 0167-5273
IS - 3
ER -