Clinical characteristics of Mikulicz's disease as an IgG4-related disease

Masafumi Moriyama, Akihiko Tanaka, takashi maehara, Yukiko Ohyama, Mayumi Shimizu, Hitoshi Nakashima, Hayashida Jun-Nosuke, Shoichi Shinozaki, Yoshiaki Kubo, Sachiko Furukawa, Toshihiro Kikuta, Seiji Nakamura

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)

抄録

Objectives: Mikulicz's disease (MD) was considered to be a subtype of Sjögren's syndrome (SS), based on histopathological similarities. However, recent studies have indicated that patients with MD show high serum IgG4 concentration, and suggested that MD is one of "IgG4-related disease" and distinguishable from SS. Therefore, we clinically and histopathologically examined the disease states of MD and SS in detail. Materials and methods: Twenty patients with Mikulicz's disease and 18 with SS were comparatively studied to determine clinical characteristics in MD patients. Results: Sialography in MD patients did not show the "apple-tree sign" typically seen in SS. Serologically, high serum IgG4 levels but not anti-SS-A or anti-SS-B antibodies were observed in MD. SS showed lymphocytic infiltration of various subsets with atrophy or severe destruction of the acini, while MD showed selective infiltration of IgG4+ plasma cells with hyperplastic germinal centers and mild acini destruction. Corticosteroid treatment of MD reduced IgG and IgG4 levels and improved salivary function. A negative correlation between disease duration and increasing rate of salivary flow was observed in MD. Conclusions: These results suggested that the pathogenesis of MD might be different from those of SS. Clinical Relevance: early diagnosis and treatment of MD is important for the improvement of salivary function.

元の言語英語
ページ(範囲)1995-2002
ページ数8
ジャーナルClinical Oral Investigations
17
発行部数9
DOI
出版物ステータス出版済み - 12 1 2013

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Mikulicz' Disease
Immunoglobulin G
Sialography
Germinal Center

All Science Journal Classification (ASJC) codes

  • Dentistry(all)

これを引用

Clinical characteristics of Mikulicz's disease as an IgG4-related disease. / Moriyama, Masafumi; Tanaka, Akihiko; maehara, takashi; Ohyama, Yukiko; Shimizu, Mayumi; Nakashima, Hitoshi; Jun-Nosuke, Hayashida; Shinozaki, Shoichi; Kubo, Yoshiaki; Furukawa, Sachiko; Kikuta, Toshihiro; Nakamura, Seiji.

:: Clinical Oral Investigations, 巻 17, 番号 9, 01.12.2013, p. 1995-2002.

研究成果: ジャーナルへの寄稿記事

Moriyama, Masafumi ; Tanaka, Akihiko ; maehara, takashi ; Ohyama, Yukiko ; Shimizu, Mayumi ; Nakashima, Hitoshi ; Jun-Nosuke, Hayashida ; Shinozaki, Shoichi ; Kubo, Yoshiaki ; Furukawa, Sachiko ; Kikuta, Toshihiro ; Nakamura, Seiji. / Clinical characteristics of Mikulicz's disease as an IgG4-related disease. :: Clinical Oral Investigations. 2013 ; 巻 17, 番号 9. pp. 1995-2002.
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abstract = "Objectives: Mikulicz's disease (MD) was considered to be a subtype of Sj{\"o}gren's syndrome (SS), based on histopathological similarities. However, recent studies have indicated that patients with MD show high serum IgG4 concentration, and suggested that MD is one of {"}IgG4-related disease{"} and distinguishable from SS. Therefore, we clinically and histopathologically examined the disease states of MD and SS in detail. Materials and methods: Twenty patients with Mikulicz's disease and 18 with SS were comparatively studied to determine clinical characteristics in MD patients. Results: Sialography in MD patients did not show the {"}apple-tree sign{"} typically seen in SS. Serologically, high serum IgG4 levels but not anti-SS-A or anti-SS-B antibodies were observed in MD. SS showed lymphocytic infiltration of various subsets with atrophy or severe destruction of the acini, while MD showed selective infiltration of IgG4+ plasma cells with hyperplastic germinal centers and mild acini destruction. Corticosteroid treatment of MD reduced IgG and IgG4 levels and improved salivary function. A negative correlation between disease duration and increasing rate of salivary flow was observed in MD. Conclusions: These results suggested that the pathogenesis of MD might be different from those of SS. Clinical Relevance: early diagnosis and treatment of MD is important for the improvement of salivary function.",
author = "Masafumi Moriyama and Akihiko Tanaka and takashi maehara and Yukiko Ohyama and Mayumi Shimizu and Hitoshi Nakashima and Hayashida Jun-Nosuke and Shoichi Shinozaki and Yoshiaki Kubo and Sachiko Furukawa and Toshihiro Kikuta and Seiji Nakamura",
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AU - Moriyama, Masafumi

AU - Tanaka, Akihiko

AU - maehara, takashi

AU - Ohyama, Yukiko

AU - Shimizu, Mayumi

AU - Nakashima, Hitoshi

AU - Jun-Nosuke, Hayashida

AU - Shinozaki, Shoichi

AU - Kubo, Yoshiaki

AU - Furukawa, Sachiko

AU - Kikuta, Toshihiro

AU - Nakamura, Seiji

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AB - Objectives: Mikulicz's disease (MD) was considered to be a subtype of Sjögren's syndrome (SS), based on histopathological similarities. However, recent studies have indicated that patients with MD show high serum IgG4 concentration, and suggested that MD is one of "IgG4-related disease" and distinguishable from SS. Therefore, we clinically and histopathologically examined the disease states of MD and SS in detail. Materials and methods: Twenty patients with Mikulicz's disease and 18 with SS were comparatively studied to determine clinical characteristics in MD patients. Results: Sialography in MD patients did not show the "apple-tree sign" typically seen in SS. Serologically, high serum IgG4 levels but not anti-SS-A or anti-SS-B antibodies were observed in MD. SS showed lymphocytic infiltration of various subsets with atrophy or severe destruction of the acini, while MD showed selective infiltration of IgG4+ plasma cells with hyperplastic germinal centers and mild acini destruction. Corticosteroid treatment of MD reduced IgG and IgG4 levels and improved salivary function. A negative correlation between disease duration and increasing rate of salivary flow was observed in MD. Conclusions: These results suggested that the pathogenesis of MD might be different from those of SS. Clinical Relevance: early diagnosis and treatment of MD is important for the improvement of salivary function.

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