Clinical correlations with dermatomyositis-specific autoantibodies in adult Japanese patients with dermatomyositis: A multicenter cross-sectional study

Yasuhito Hamaguchi, Masataka Kuwana, Kana Hoshino, Minoru Hasegawa, Kenzo Kaji, Takashi Matsushita, Kazuhiro Komura, Motonobu Nakamura, Masanari Kodera, Norihiro Suga, Akira Higashi, Koji Ogusu, Kiyohiro Tsutsui, Akira Furusaki, Hiroshi Tanabe, Shunsuke Sasaoka, Yoshinao Muro, Mika Yoshikawa, Naoko Ishiguro, Masahiro AyanoEiji Muroi, Keita Fujikawa, Yukihiro Umeda, Masaaki Kawase, Eriko Mabuchi, Yoshihide Asano, Kinuyo Sodemoto, Mariko Seishima, Hidehiro Yamada, Shinichi Sato, Kazuhiko Takehara, Manabu Fujimoto

研究成果: Contribution to journalArticle査読

208 被引用数 (Scopus)

抄録

Objective: To clarify the association of clinical and prognostic features with dermatomyositis (DM)-specific autoantibodies (Abs) in adult Japanese patients with DM. Design: Retrospective study. Setting: Kanazawa University Graduate School of Medical Science Department of Dermatology and collaborating medical centers. Patients: A total of 376 consecutive adult Japanese patients with DM who visited our hospital or collaborating medical centers between 2003 and 2008. Main Outcome Measures: Clinical and laboratory characteristics of adult Japanese patients with DM and DMspecific Abs that include Abs against Mi-2, 155/140, and CADM-140. Results: In patients with DM, anti-Mi-2, anti-155/140, and anti-CADM-140 were detected in 9 (2%), 25 (7%), and 43 (11%), respectively. These DM-specific Abs were mutually exclusive and were detected in none of 34 patients with polymyositis, 326 with systemic sclerosis, and 97 with systemic lupus erythematosus. Anti-Mi-2 was associated with classical DM without interstitial lung disease or malignancy, whereas anti-155/140 was associated with malignancy. Patients with anti-CADM-140 frequently had clinically amyopathic DM and rapidly progressive interstitial lung disease. Cumulative survival rates were more favorable in patients with anti-Mi-2 compared with those with anti-155/140 or anti-CADM-140 (P < .01 for both comparisons). Nearly all deaths occurred within 1 year after diagnosis in patients with anti-CADM-140. Conclusion: Dermatomyositis-specific Abs define clinically distinct subsets and are useful for predicting clinical outcomes in patients with DM.

本文言語英語
ページ(範囲)391-398
ページ数8
ジャーナルArchives of Dermatology
147
4
DOI
出版ステータス出版済み - 4 2011
外部発表はい

All Science Journal Classification (ASJC) codes

  • 皮膚病学

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