Clinical efficacy of basic fibroblast growth factor (bFGF) for diabetic ulcer

Uchi Hiroshi, Atsuyuki Igarashi, Kazunori Urabe, Tetsuya Koga, Juichiro Nakayama, Ryuzo Kawamori, Kunihiko Tamaki, Hideki Hirakata, Takehiko Ohura, Masutaka Furue

研究成果: ジャーナルへの寄稿学術誌査読

120 被引用数 (Scopus)

抄録

Basic fibroblast growth factor (bFGF) has been shown to promote wound healing. The present trial evaluated the clinical efficacy of bFGF for diabetic ulcer, a type of refractory skin ulcer, and the doseresponse relationship. This was designed as a randomized, doubleblind, dose-ranging, placebo-controlled trial. A total of 150 patients with non-ischaemic diabetic ulcers measuring 900 mm2 or less were randomized into a placebo group (n = 51), a 0.001% bFGF group (n = 49) and a 0.01% bFGF group (n = 50), and 148 of these patients received treatment for 8 weeks or less. The efficacy evaluation was carried out on 139 patients who met the protocol in this trial. The primary outcome was the percentage of patients showing 75% or greater reductions in the area of ulcer. The area of ulcer decreased by 75% or more in 57.5% (27/47), 72.3% (34/47), and 82.2% (37/45) in the placebo, 0.001% bFGF and 0.01% bFGF groups, respectively, and differences were significant between the 0.01% bFGF and placebo groups (p = 0.025). The cure rate was 46.8% (22/47), 57.4% (27/47), and 66.7% (30/45) in the placebo, 0.001% bFGF and 0.01% bFGF groups, respectively. The findings obtained in this trial showed wound healing accelerating effects of bFGF on diabetic ulcers.

本文言語英語
ページ(範囲)461-468
ページ数8
ジャーナルEuropean Journal of Dermatology
19
5
DOI
出版ステータス出版済み - 9月 1 2009

!!!All Science Journal Classification (ASJC) codes

  • 皮膚病学

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