Clinical efulness of Measurement of Serum Fructosamine in Diabetics: Influence of Renal Failure, Liver Cirrhosis, and Thyroid Dysfunction

Yasuhiro Sako, Fumio Umeda, Toshihiko Hashimoto, Toyoshi Inoguchi, Kazuo Mimura, Makoto Kunisaki, Yuji Tajiri, Hidehiro Ishii, Tsukasa Yamashita, Teruaki Yamauchi, Hajime Nawata

    研究成果: Contribution to journalArticle査読

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    Measurement of serum fructosamine (FRA) by means of a Roche kit is a simple and reliable method for estimating glycosylated serum proteins. The level of FRA can be affected by hyperglycemia in diabetics and an abnormal metabolic state of serum proteins such as albumin in patients with renal failure, liver cirrhosis, and thyroid dysfunction. We measured FRA in diabetics and these patients. The average FRA level was 2.58 ± 0.08 (mean ± SE) mmol/l in the normal controls (n=18), 4.60±0.67 in patients with IDDM (n=8), and 3.61±0.10 in patients with NIDDM (n=63). In the patients with non-diabetic renal failure, while the FRA level was significantly (p<0.05) low, FRA corrected by total protein concentration was not different from that of the normal controls. The FRA level in liver cirrhosis without hyperbilirubinemia was not significantly different from that of normal controls. In the patients with thyroid disease, the FRA level was 2.08±0.03 in hyperthyroidism and 3. 11 ±0.07 in hypothyroidism. Moreover, the FRA level was negatively correlated with the thyroid hormones T3 and T4 (p<0.001). It is concluded that measurement of FRA is clinically useful for evaluating short-term glycemic control in diabetics even when there is complicating nephropathy or liver cirrhosis. However, its level in diabetic patients with hyperbilirubinemia or thyroid dysfunction must be cautiously interpreted.

    本文言語英語
    ページ(範囲)929-935
    ページ数7
    ジャーナルJournal of the Japan Diabetes Society
    31
    12
    DOI
    出版ステータス出版済み - 1988

    All Science Journal Classification (ASJC) codes

    • 内科学
    • 内分泌学、糖尿病および代謝内科学
    • 内分泌学

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