Clinical features and chromosomal/genetic aberration in adult acute lymphoblastic leukemia in Japan: results of Fukuoka Blood & Marrow Transplant Group Studies ALL MRD 2002 and 2008

Satoshi Morishige, Toshihiro Miyamoto, Tetsuya Eto, Naoyuki Uchida, Tomohiko Kamimura, Yasuhiko Miyazaki, Ryosuke Ogawa, Hirokazu Okumura, Tomoaki Fujisak, Hiromi Iwasaki, Noriaki Kawano, Atsushi Wake, Takanori Ohta, Yasushi Takamatsu, Toshiro Kurokawa, Yoshikiyo Ito, Takahiro Maeda, Koichi Akashi, Koji Nagafuji

研究成果: Contribution to journalArticle査読

抄録

Acute lymphoblastic leukemia (ALL) is a common neoplasm in children, but less frequent in adults. Since information on clinical features and genetics of adult ALL in Japan is limited, we analyzed 215 subjects aged 16–65 years with untreated ALL enrolled in the Fukuoka Blood & Marrow Transplant Group studies ALL MRD 2002 and 2008. The prevalence of ALL was bimodal, with the larger group aged 56–65 years. Immunophenotypic characterization showed B-lineage is more frequent than T-lineage ALL (78.6 vs 13.0%), with age-related differences. The proportion with BCR-ABL1 rearrangement increased progressively with age, up to 55.7% among subjects aged over 56–65 years. Rearrangements involving the KMT2A gene, ETV6-RUNX1, and TCF3-PBX1 were rare in this study cohort. The overall incidence of hyperdiploidy was only 1.7%, and there were no cases with hypodiploidy. Overall survival varied by age and cytogenetics. Older subjects and those with BCR-ABL1 tended to have inferior outcomes. In this epidemiological study of Japanese adult ALL, the majority of subjects had B-lineage ALL, the T-cell phenotype was most frequent in those aged 16–25, and BCR-ABL1 rearrangement was very common, with prevalence increasing with age. These types of adult ALL are potentially manageable with targeted therapies.

本文言語英語
ページ(範囲)815-822
ページ数8
ジャーナルInternational journal of hematology
113
6
DOI
出版ステータス出版済み - 6 2021

All Science Journal Classification (ASJC) codes

  • 血液学

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