Clinical importance of intraoperative peritoneal cytology in patients with pancreatic cancer

Toshiya Abe, Kenoki Ouchida, Sho Endo, Fumihiko Ookubo, Yasuhisa Mori, Kohei Nakata, Yoshihiro Miyasaka, Tatsuya Manabe, Ohtsuka Takao, Eishi Nagai, Yoshinao Oda, Masafumi Nakamura

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

抄録

Background The clinical importance of intraoperative peritoneal cytology in patients with pancreatic cancer remains incompletely understood. Methods Peritoneal washing samples were collected from 411 consecutive patients with pancreatic ductal adenocarcinoma from 1996 to 2014. Of the 411 patients, 335 underwent macroscopically curative resection and 76 with noncurative factors did not undergo resection. We compared long-term outcomes between patients with positive cytology (cytology+) and those with negative cytology (cytology−) and investigated the importance of clinicopathologic factors. Results Of 335 patients with curative resection, 300 (89.6%) were cytology− and 35 (10.4%) were cytology+. The median overall survival of cytology+ patients was less than that of cytology− patients (16 vs 31 months, respectively; P < .0001). The median overall survival of cytology+ patients with noncurative factors was significantly worse than that of cytology+ patients with curative resection (6.9 vs 16.0 months, respectively; P = .0023). The median disease-free survival of cytology+ patients was less than that of cytology− patients (6.5 vs 16 months, respectively; P < .0001). In the multivariate analysis, cytology+ was an independent prognostic factor for overall survival and disease-free survival. Conclusion Cytology+ without noncurative factors was a predictive factor for a poor prognosis. Therefore, it is important to regard patients with pancreatic cancer characterized by cytology+ as a special group that may warrant more aggressive adjuvant therapy.

元の言語英語
ページ(範囲)951-958
ページ数8
ジャーナルSurgery (United States)
161
発行部数4
DOI
出版物ステータス出版済み - 4 1 2017

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Pancreatic Neoplasms
Cell Biology
Disease-Free Survival
Survival
Adenocarcinoma

All Science Journal Classification (ASJC) codes

  • Surgery

これを引用

Clinical importance of intraoperative peritoneal cytology in patients with pancreatic cancer. / Abe, Toshiya; Ouchida, Kenoki; Endo, Sho; Ookubo, Fumihiko; Mori, Yasuhisa; Nakata, Kohei; Miyasaka, Yoshihiro; Manabe, Tatsuya; Takao, Ohtsuka; Nagai, Eishi; Oda, Yoshinao; Nakamura, Masafumi.

:: Surgery (United States), 巻 161, 番号 4, 01.04.2017, p. 951-958.

研究成果: ジャーナルへの寄稿記事

Abe, Toshiya ; Ouchida, Kenoki ; Endo, Sho ; Ookubo, Fumihiko ; Mori, Yasuhisa ; Nakata, Kohei ; Miyasaka, Yoshihiro ; Manabe, Tatsuya ; Takao, Ohtsuka ; Nagai, Eishi ; Oda, Yoshinao ; Nakamura, Masafumi. / Clinical importance of intraoperative peritoneal cytology in patients with pancreatic cancer. :: Surgery (United States). 2017 ; 巻 161, 番号 4. pp. 951-958.
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abstract = "Background The clinical importance of intraoperative peritoneal cytology in patients with pancreatic cancer remains incompletely understood. Methods Peritoneal washing samples were collected from 411 consecutive patients with pancreatic ductal adenocarcinoma from 1996 to 2014. Of the 411 patients, 335 underwent macroscopically curative resection and 76 with noncurative factors did not undergo resection. We compared long-term outcomes between patients with positive cytology (cytology+) and those with negative cytology (cytology−) and investigated the importance of clinicopathologic factors. Results Of 335 patients with curative resection, 300 (89.6{\%}) were cytology− and 35 (10.4{\%}) were cytology+. The median overall survival of cytology+ patients was less than that of cytology− patients (16 vs 31 months, respectively; P < .0001). The median overall survival of cytology+ patients with noncurative factors was significantly worse than that of cytology+ patients with curative resection (6.9 vs 16.0 months, respectively; P = .0023). The median disease-free survival of cytology+ patients was less than that of cytology− patients (6.5 vs 16 months, respectively; P < .0001). In the multivariate analysis, cytology+ was an independent prognostic factor for overall survival and disease-free survival. Conclusion Cytology+ without noncurative factors was a predictive factor for a poor prognosis. Therefore, it is important to regard patients with pancreatic cancer characterized by cytology+ as a special group that may warrant more aggressive adjuvant therapy.",
author = "Toshiya Abe and Kenoki Ouchida and Sho Endo and Fumihiko Ookubo and Yasuhisa Mori and Kohei Nakata and Yoshihiro Miyasaka and Tatsuya Manabe and Ohtsuka Takao and Eishi Nagai and Yoshinao Oda and Masafumi Nakamura",
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T1 - Clinical importance of intraoperative peritoneal cytology in patients with pancreatic cancer

AU - Abe, Toshiya

AU - Ouchida, Kenoki

AU - Endo, Sho

AU - Ookubo, Fumihiko

AU - Mori, Yasuhisa

AU - Nakata, Kohei

AU - Miyasaka, Yoshihiro

AU - Manabe, Tatsuya

AU - Takao, Ohtsuka

AU - Nagai, Eishi

AU - Oda, Yoshinao

AU - Nakamura, Masafumi

PY - 2017/4/1

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N2 - Background The clinical importance of intraoperative peritoneal cytology in patients with pancreatic cancer remains incompletely understood. Methods Peritoneal washing samples were collected from 411 consecutive patients with pancreatic ductal adenocarcinoma from 1996 to 2014. Of the 411 patients, 335 underwent macroscopically curative resection and 76 with noncurative factors did not undergo resection. We compared long-term outcomes between patients with positive cytology (cytology+) and those with negative cytology (cytology−) and investigated the importance of clinicopathologic factors. Results Of 335 patients with curative resection, 300 (89.6%) were cytology− and 35 (10.4%) were cytology+. The median overall survival of cytology+ patients was less than that of cytology− patients (16 vs 31 months, respectively; P < .0001). The median overall survival of cytology+ patients with noncurative factors was significantly worse than that of cytology+ patients with curative resection (6.9 vs 16.0 months, respectively; P = .0023). The median disease-free survival of cytology+ patients was less than that of cytology− patients (6.5 vs 16 months, respectively; P < .0001). In the multivariate analysis, cytology+ was an independent prognostic factor for overall survival and disease-free survival. Conclusion Cytology+ without noncurative factors was a predictive factor for a poor prognosis. Therefore, it is important to regard patients with pancreatic cancer characterized by cytology+ as a special group that may warrant more aggressive adjuvant therapy.

AB - Background The clinical importance of intraoperative peritoneal cytology in patients with pancreatic cancer remains incompletely understood. Methods Peritoneal washing samples were collected from 411 consecutive patients with pancreatic ductal adenocarcinoma from 1996 to 2014. Of the 411 patients, 335 underwent macroscopically curative resection and 76 with noncurative factors did not undergo resection. We compared long-term outcomes between patients with positive cytology (cytology+) and those with negative cytology (cytology−) and investigated the importance of clinicopathologic factors. Results Of 335 patients with curative resection, 300 (89.6%) were cytology− and 35 (10.4%) were cytology+. The median overall survival of cytology+ patients was less than that of cytology− patients (16 vs 31 months, respectively; P < .0001). The median overall survival of cytology+ patients with noncurative factors was significantly worse than that of cytology+ patients with curative resection (6.9 vs 16.0 months, respectively; P = .0023). The median disease-free survival of cytology+ patients was less than that of cytology− patients (6.5 vs 16 months, respectively; P < .0001). In the multivariate analysis, cytology+ was an independent prognostic factor for overall survival and disease-free survival. Conclusion Cytology+ without noncurative factors was a predictive factor for a poor prognosis. Therefore, it is important to regard patients with pancreatic cancer characterized by cytology+ as a special group that may warrant more aggressive adjuvant therapy.

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